Fig 1: CCL+ macrophages are enriched in the synovial tissue of patients with ACPA- RA.a Violin plots showing the differences in the expression of HLA-DRB5, CCL3, CCL13, CCL18, and MMP3 between ACPA- and ACPA+ macrophage subtypes in STMC. Asterisks indicate the significance. P values were calculated by the two-sided Wilcoxon test. *p < 0.05, **p < 0.01, ***p < 0.001. b Immunohistochemistry of CCL3, CCL13, and CCL18 expression in the synovial tissue of 3 OA, 3 ACPA- RA, and 3 ACPA+ RA patients. The immunohistochemistry results were carried out in one independent experiment of three biological replicates from each group.
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