Fig 1: The changes in CD68+ mononuclear cells at baseline and post-treatment. a: Representative images of CD68+ mononuclear cells at baseline and post-treatment from samples of case 231,167 (FIER groups) and case 312,134 (FIENR groups) evaluated by multiplex immunohistochemical staining. 200× magnification. PID: Patient ID. b: The changes in the levels of CD68+ mononuclear cells at baseline and post-treatment in the FIER groups (n = 7). c: The changes in the levels of CD68+ mononuclear cells at baseline and post-treatment in the FIENR groups (n = 9). d: The levels of CD68+ mononuclear cells between the FIER groups (n = 7) and the FIENR groups (n = 9) at baseline. e: Representative images of CD49A+MARCO+CD68+ mononuclear cells at baseline from samples of case 232,643 (FIER groups) evaluated by multiplex immunohistochemical staining. 400× magnification. PID: Patient ID. f: The changes in the levels of CD49A+MARCO+CD68+ mononuclear cells at baseline and post-treatment in the FIER groups (n = 6). One patient’s section had been dissected during the experiment, so it was not counted