Fig 1: Nrf2 contributes to As3+-induced expression of CEBPB, HSPA1B and UBE2G2 (A). Screenshot for the indicated genes in ChIP-seq showing As3+-induced enhanced enrichment of Nrf2 (pointed by red arrows) and HIF1a (pointed by green arrows) (B,C). Western blotting and quantification of the Western blotting data from 3 independent experiments for CEBPB (B) and HSPA1B (C).
Fig 2: Regulation of ER stress activated unfolded protein response (UPR) by As3+ (A). As3+ upregulated UPR genes ATF6, CEBPB, HSPA1B, MAPK10, UBE2G2 in BEAS2B cells. Data are fold-changes of these genes in UPR array for the As3+-treated cells relative to the control cells. Only the genes that had more than 2-fold induction by a treatment of the cells with 2 µM As3+ for 6 h are shown (B). Downregulated UPR genes, ERN2, HTRA4, SCAP, by As3+. Only the genes with more than 1.2-fold downregulation are shown.
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