Fig 1: Investigations of the functions of FOSB in CCA. (A) Reverse transcription-quantitative PCR analysis of FOSB gene expression in cancerous and paracancerous tissues of 12 patients with CCA. (B) Western blot evaluation of FOSB protein in cancerous and paracancerous tissues of patients with CCA. (C) Impact of FOSB expression on the viability/proliferation of HUCCT1 cells determined by a Cell Counting Kit-8 assay. *P<0.05; **P<0.01. NC, negative control; FOSB-OE, FOSB-overexpression; FOSB-LE, FOSB low expression; FOSB, FBJ murine osteosarcoma viral oncogene homolog B; CCA, cholangiocarcinoma.
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