Fig 1: MND1 expression is association with clinicopathological characteristics in patients with KIRC. Increased MND1 expression was significantly with (A) Gender, (B) Grade, (C) Stage, (D) Tumor size, (E) Metastasis and (F) Node.
Fig 2: MND1 expression in tumor tissues is associated with poor survival in KIRC patients. (A) Associations with overall survival and the expression of MND1 in TCGA patients. (B) Multivariate Cox analysis of MND1.
Fig 3: Genes differentially expressed in correlation with MND1 and enriched GO annotations, KEGG pathways of MND1 correlated genes in KIRC. (A) Pearson test was used to analyze association between MND1 and genes differently expressed in KIRC, red indicates positively correlated genes and green indicates negatively correlated genes. (B, C) The genes positively and negatively relative to MND1 in KIRC were showed by heat maps. (D), Enriched GO annotations of MND1 correlated genes in KIRC, including biological processes (BP), molecular function (MF), and cell component (CC) (P<0.05). (E) Significant KEGG pathways most associated with MND1.
Fig 4: The expression of MND1 in different datasets. (A) The mRNA level of MND1 in 33 kinds of tumor types from TIMER. (**p<0.01, ***p<0.001). (B) Expression levels of MND1 were higher than non-tumor tissues in KIRC samples(p=2.451e-28). (C) MND1 expression of KIRC tissues and corresponding normal tissues downloaded from TCGA RNA-seq datasets(p=5.824e-16). (D) MND1 expression is significantly regulated in KIRC in the GSE105288. (E) Typical images of IHC in 30 pairs of KIRC tissues showing the protein expression of MND1 in KIRC and adjacent nontumor tissues.
Fig 5: Protein–protein interaction network of related gene (Top200) and analysis of hub genes in KIRC. (A) Protein–protein interaction based on (PPI) network (B), MCODE analysis indicating the hub genes CDK1, CDC20, CCNB1, highlighted in yellow. (C) Correlation between MND1 and the mRNA expression of CDK1, CDC20 and CCNB1 in KIRC determined using GEPIA. (D) Prognosis analysis of correlational genes.
Supplier Page from Abcam for Anti-MND1 antibody