Fig 1: Cutaneous inflammatory lesions induced by UVB irradiation in Nlrp1b KI mice. (A–C) Clinical features of Nlrp1b KI (homo) mice (A), Nlrp1b KI (hetero) mice (B), and WT mice (C) at 5 weeks of age, 9 days after UVB irradiation. (n?3) The Nlrp1b KI mice (A, B) show many scales on the back. (D–F) Hematoxylin and eosin staining of the skin samples reveals acanthosis, hyperkeratosis, inflammatory cell infiltration (D, E), and dyskeratosis (D, E insert) in the Nlrp1b KI mice, but such features are not seen or are mild in the WT mice (F) (original magnification ×200). (G–I) Inflammatory cell infiltration in the epidermis stained positive for IL-1b (original magnification × 400).