Fig 1: A and B. Box plots of plasma Dickkopf-1 (Dkk-1, pg/mL) in Charcot patients (n = 24), diabetic controls (n = 20), and healthy subjects (n = 20) at inclusion (A) and at termination of the study after 2 years (B). C. Trajectory of plasma Dkk-1 in Charcot patients throughout the observation period of 2 years, based on repeated sampling over time and relative to diabetic controls and healthy subjects. Mean (SEM). a p = 0.009 for Charcot patients at 4 months vs. Charcot patients at inclusion; b p = 0.01 for Charcot patients at 2 years vs. Charcot patients at inclusion, as analyzed by Mann-Whitney rank sum test.