Caspase-8 Antibody 4927S from Cell Signaling Technology

Product Specs
ItemCaspase-8 Antibody
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number4927S
Quantity100 µl
ApplicationsW
ReactivityM
TargetCasp8 mouse
HostRabbit
NCBI Gene AliasesCASP-8, FLICE, MACH, Mch5
NCBI Full Gene Namecaspase 8
ClonalityPolyclonal
Research AreaApoptosis
Molecular Weight45, 57

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Pathogen-driven nucleotide overload triggers mitochondria-centered cell death in phagocytesPLoS PathogDecember 29, 2023Nicoletta Schwermann, Rita Haller, Sebastian Koch, Guntram A. Grassl, Volker Winstelrabbit primary antibodies: α-Caspase-8 (α-CASP8, ab32397, Abcam; human cells), α-Caspase-8 (α-CASP8, 4927, Cell Signaling; murine cells), α-Caspase-9 (α-CASP9, ab202068, Abcam), α-APAF1 (α-APAF1, ab234436,

(2) TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathyPLOS ONENovember 28, 2023Maja Wyczanska, Jana Rohling, Ursula Keller, Marcus R. Benz, Carsten Kirschning, Bärbel Lange-Sperandio(ThermoFisher Scientific, MA, #MA5-32787, 1:1000), Caspase-8 antibody (Cell Signaling Technology, MA, #4927, 1:1000), Bcl-2 antibody (Santa Cruz, Germany, sc7382, 1:200), Bax antibody (Cell Signaling Technology,

(3) ZBP1 Drives IAV-Induced NLRP3 Inflammasome Activation and Lytic Cell Death, PANoptosis, Independent of the Necroptosis Executioner MLKLVirusesOctober 24, 2023R. K. Subbarao Malireddi, Bhesh Raj Sharma, Ratnakar R. Bynigeri, Yaqiu Wang, Jianlin Lu, Thirumala-Devi Kanneganti(#9661, CST, 1:1000), caspase-7 (#9492, CST, 1:1000), cleaved caspase-7 (#9491, CST, 1:1000), caspase-8 (#4927, CST, 1:1000), cleaved caspase-8 (#8592, CST, 1:1000), GSDMD (ab209845, Abcam, Waltham, MA, USA, 1:1000),

(4) Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targetsCommunications BiologyOctober 20, 2023R. K. Subbarao Malireddi, Ratnakar R. Bynigeri, Raghvendra Mall, Jon P. Connelly, Shondra M. Pruett-Miller, Thirumala-Devi Kannegantianti-caspase-7 (CST, #9492, 1:1000), anti-cleaved caspase-7 (CST, #9491, 1:1000), anti-caspase-8 (CST, #4927, 1:1000), anti-cleaved caspase-8 (CST, #8592, 1:1000), anti-GSDMD (Abcam, ab209845, 1:1000), anti-GSDME

(5) Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis)Journal of Biological ChemistrySeptember 1, 2023Bhesh Raj Sharma, Rajendra Karki, Yetirajam Rajesh, Thirumala-Devi Kanneganti(CST; catalog no.: 9492), cleaved caspase-7 (CST; catalog no.: 9491), caspase-8 (CST; catalog no.: 4927), cleaved caspase-8 (CST; catalog no.: 8592), caspase-1 (AdipoGen; catalog no.: AG-20B-0042), GAPDH

(6) Repression of ferroptotic cell death by mitochondrial calcium signalingResearch squareJuly 10, 2023Chen J, Zhao B, Wang S, Ma A, Dong H, Cheng X, Lin S, Li X, Herring LE, Xin G, et al.anti-FLAG (A01869, GenScript), anti-Caspase 1 (4199T, CST),anti-Caspase 3 (14220T, CST), anti-Caspase 8 (4927S, CST), anti-p-PDH (31866S, CST), anti-RIPK1 (3493S, CST), anti-p-RIPK3 (31122S, CST), anti-RIPK3 (NBP1–77299,

(7) AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathwayEMBO Molecular MedicineJuly 10, 2023Yalan Cheng, Zhentong Zhang, Peidong Gao, Hejin Lai, Wuling Zhong, Ning Feng, Yale Yang, Huimin Yu, Yali Zhang, Yumo Han, et al.9661, 1:1,000), Caspase‐3 (CST, 9662, 1:1,000), cleaved Caspase‐8 (CST, 9429, 1:1,000), Caspase‐8 (CST, 4927, 1:1,000), and GAPDH (CST, 2118, 1:5,000). The immune complexes were detected using a horseradish peroxidase‐conjugated

(8) Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial FunctionJournal of the American Heart AssociationJune 20, 2023Pavel Zhabyeyev, Brent McLean, Wesam Bassiouni, Robert Valencia, Manish Paul, Ahmed M. Darwesh, John M. Seubert, Saugata Hazra, Gavin Y. Oudit4695), P‐ERK 1/2 (Cell Signaling, 4377), Caspase 3 (Cell Signaling, 9662), Caspase 8 (Cell Signaling, 4927), phospho‐receptor‐interacting serine/threonine‐protein kinase 1 (RIP‐1) (Cell Signaling, 3493), RIP‐3

(9) Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosisiScienceJune 16, 2023R.K. Subbarao Malireddi, Ratnakar R. Bynigeri, Raghvendra Mall, Eswar Kumar Nadendla, Jon P. Connelly, Shondra M. Pruett-Miller, Thirumala-Devi Kanneganti(#9661, CST, 1:1000), caspase-7 (#9492, CST, 1:1000), cleaved caspase-7 (#9491, CST, 1:1000), caspase-8 (#4927, CST, 1:1000), cleaved caspase-8 (#8592, CST, 1:1000), GSDMD (ab209845, Abcam, 1:1000), GSDME (ab19859,

(10) O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosisFrontiers in ImmunologyJune 9, 2023Junghwa Seo, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Eugene C. Yi, Yong-ho Lee, Injae Shin, Won Ho Yang, Jin Won Cho(Cell Signaling, #9762s), anti-Caspase 7 (Cell Signaling, #9492s), anti-Caspase 8 (Cell Signaling, #4927s), anti-RIPK1 (BD Biosciences, #610459 for IP), anti-RIPK1 (Cell Signaling, #34935s for WB), anti-mouse-phospho-S166-RIPK1

(11) XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated deathCell death & diseaseApril 11, 2023Witt A, Goncharov T, Lee YM, Kist M, Dohse M, Eastham J, Dugger D, Newton K, Webster JD, Vucic D.caspase-1(Genentech), caspase-3 (#9661, 9662, CST), caspase-7(#9491, CST), caspase-8 (#8592, 9429, 4927, CST), caspase-11(#14340, CST), GSDMD (#50928, CST), IL-1b (AF-401-NA, R&D), JNK(#9252, CST), pJNK (#4668,

(12) Tectorigenin alleviates the apoptosis and inflammation in spinal cord injury cell model through inhibiting insulin-like growth factor-binding protein 6Open Med (Wars)April 11, 2023Liqiang Zhou, Kui Yan, Shuxing Xing, Jun Chengcaspase-3 (#9662, rabbit antibody, 30 kDa, dilution 1:1000, Cell signaling technology), caspase-8 (#4927, rabbit antibody, 57 kDa, dilution 1:1000, Cell signaling technology), caspase-9 (#9504, rabbit antibody,

(13) KPT‐330 and Y219 exert a synergistic antitumor effect in triple‐negative breast cancer through inhibiting NF‐κB signalingFEBS Open BioApril 1, 2023Tiantian Wen, Mengzhu Geng, Enhe Bai, Xueyuan Wang, Hang Miao, Zhimeng Chen, Hui Zhou, Jia Wang, Jingmiao Shi, Yin Zhang, et al.imaging reagents (ECL; Servicebio, Wuhan, Hubei, China). Primary antibodies: Caspase‐3 (9662), Caspase‐8 (4927), Caspase‐9 (9502), RAPR (9532), Cyto‐c (11940), IκB‐α (9242), β‐actin (4970), p65 (8242S), Lamin B1

(14) IFNγ is a central node of cancer immune equilibriumCell ReportsMarch 28, 2023Michael J. Walsh, Courtney T. Stump, Rakeeb Kureshi, Patrick Lenehan, Lestat R. Ali, Michael Dougan, David M. Knipe, Stephanie K. Douganconfirmed by Western blot as described previously51 using anti-caspase 8 primary antibody (Cell Signaling #4927) and anti-GAPDH (abcam 8245). Recombinant herpes simplex virus generation The pd27-IL12 shuttle plasmid

(15) CARD-only proteins regulate in vivo inflammasome responses and ameliorate goutCell reportsMarch 28, 2023Devi S, Indramohan M, Jäger E, Carriere J, Chu LH, de Almeida L, Greaves DR, Stehlik C, Dorfleutner A.anti-caspase-9 (Cell Signaling Technology, #9504), rabbit polyclonal anti-caspase-8 (Cell Signaling Technology, #4927). rabbit monoclonal anti-caspase-3 (Cell Signaling Technology, #14220) and rabbit polyclonal cleaved

(16) THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell massNature communicationsFebruary 23, 2023Zhang Y, Han S, Liu C, Zheng Y, Li H, Gao F, Bian Y, Liu X, Liu H, Hu S, et al.anti-cleaved caspase-8 (Cell Signaling Technology, #8592), anti-caspase-8 (Cell Signaling Technology, #4927), anti-cleaved caspase-3 (Cell Signaling Technology, #9664), anti-ATF4 (Cell Signaling Technology, #11815),

(17) Renin–Angiotensin System Antagonism Protects the Diabetic Heart from Ischemia/Reperfusion Injury in Variable Hyperglycemia Duration Settings by a Glucose Transporter Type 4-Mediated PathwayPharmaceuticals (Basel)February 3, 2023Aisha Al-Kouh, Fawzi Babiker, Maie Al-Baderanti-phosphorylated ERK1/2 antibody (cat #9743); anti-caspase-3 antibody (cat #9662); anti-caspase-8 antibody (cat #4927); anti-phosphorylated endothelial nitric oxide synthase (eNOS) (Ser1177) antibody (cat #9571); anti-eNOS

(18) EVA1A regulates hematopoietic stem cell regeneration via ER-mitochondria mediated apoptosisCell death & diseaseJanuary 30, 2023Liu B, Zhou Y, Wu Q, Fu Y, Zhang X, Wang Z, Yi W, Wang H, Chen Z, Song Z, et al.IRE1: 14C10, CST; ATF6: 65880 T, CST; Actin: AC026, ABclonal; Flag: 20543-1-AP, Proteintech; Caspase 8: 4927, CST; C-Caspase 9: 9509, CST; C-Caspase 3: 9664, CST; Caspase 12: 2202, CST; C-Parp: 9548, CST; GFP:

(19) Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunityBreast Cancer ResearchJanuary 26, 2023Zhaoshan Liu, Swati Choksi, Hyung-Joon Kwon, Delong Jiao, Chengyu Liu, Zheng-gang LiuAbcam; anti-cleaved Caspase3 (9664), anti-Caspase3 (9662), anti-cleaved Caspase8 (8592), anti-Caspase8 (4927), anti-cleaved Caspase9 (9509), anti-Caspase9 (9508) antibodies from Cell signaling; β-actin (A3853)

(20) Evaluation of Caspase Activation to Assess Innate Immune Cell DeathJournal of visualized experiments : JoVEJanuary 20, 2023Han JH, Tweedell RE, Kanneganti TD.,Cell Signaling Technology,9662, Anti–caspase-7 antibody,Cell Signaling Technology,9492, Anti–caspase-8 antibody,Cell Signaling Technology,4927, Anti–caspase-9 antibody,Cell Signaling Technology,9504, Anti–cleaved caspase-3 antibody,Cell Signaling Technology

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Caspase-8 Antibody from Cell Signaling Technology

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Caspase-8 Antibody from Cell Signaling Technology

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