PLCgamma1 Antibody 2822S from Cell Signaling Technology

Product Specs
ItemPLCgamma1 Antibody
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number2822S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R
TargetPLCg1
HostRabbit
NCBI Gene AliasesNCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
NCBI Full Gene Namephospholipase C gamma 1
ClonalityPolyclonal
Research AreaCa, cAMP and Lipid Signaling
Molecular Weight155

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cellGut MicrobesDecember 18, 2023Xinhai Zhu, Ke Li, Guichao Liu, Ruan Wu, Yan Zhang, Siying Wang, Meng Xu, Ligong Lu, Peng Lip-Lck (CST, 70926S), p-Zap70 (CST, 2717), Zap70 (CST, 2705), LAT (9166), p-LAT (CST, 3584), PLCγ1 (CST, 2822), p-PLCγ1 (14008), PD-L1 (Abcam, ab213480), and β-actin (CST, 3700). The following secondary antibodies

(2) AAV-BDNF gene therapy ameliorates a hypothalamic neuroinflammatory signature in the Magel2-null model of Prader-Willi syndromeMolecular Therapy - Methods & Clinical DevelopmentDecember 14, 2023Nicholas J. Queen, Wei Huang, Xunchang Zou, Xiaokui Mo, Lei Cao(Tyr783) (p-PLC γ1 (Tyr783), Cell Signaling # 14008, 1:500), Total PLCγ1 (t-PLCγ1, Cell Signaling # 2822, 1:1,000), Ras (Cell Signaling # 3965, 1:1,000). HA tag (Cell Signaling #3724T, 1:1,000). Chemiluminescence

(3) Cell-based screen identifies porphyrins as FGFR3 activity inhibitors with therapeutic potential for achondroplasia and cancerJCI InsightNovember 22, 2023Yun-Wen Lin, Hsiao-Jung Kao, Wei-Ting Chen, Cheng-Fu Kao, Jer-Yuarn Wu, Yuan-Tsong Chen, Yi-Ching LeeMAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, 4376), PLCγ1 (Cell Signaling Technology, 2822), PI3K p85 (Cell Signaling Technology, 4257), STAT1 (Cell Signaling Technology, 14994), AKT (pan) (Cell Signaling Technology

(4) Associating bovine herpesvirus 1 envelope glycoprotein gD with activated phospho-PLC-γ1(S1248)Microbiology SpectrumOctober 17, 2023Chang Liu, Weifeng Yuan, Hao Yang, Junqing Ni, Linke Tang, Heci Zhao, Donna Neumann, Xiuyan Ding, Liqian Zhufollowing antibodies were used in this study: p-PLC-γ1(Ser1248) rabbit mAb (cat# 8713), PLC-γ1 pAb (cat# 2822S), β-actin rabbit mAb (cat# 4970), horseradish peroxidase (HRP)-conjugated goat anti-mouse IgG (cat#

(5) Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/SrcJournal of Clinical InvestigationOctober 16, 2023Elin Sjöberg, Marit Melssen, Mark Richards, Yindi Ding, Catarina Chanoca, Dongying Chen, Emmanuel Nwadozi, Sagnik Pal, Dominic T. Love, Takeshi Ninchoji, et al.anti-phospho-PLCγ1 (Tyr783) (Cell signaling technology, 2821s), rabbit anti-PLCγ1 (Cell signaling technology, 2822s), and goat anti–VE-cadherin (R&D systems, AF1002). pVEC Y685 antibody used for in vivo and in vitro

(6) Fibroblast Growth Factor 23 Signaling Does Not Increase Inflammation from Pseudomonas aeruginosa Infection in the Cystic Fibrosis Bronchial EpitheliumMedicina (Kaunas)September 9, 2023Meghan June Hirsch, Emma Lea Matthews, Seth Bollenbecker, Molly Easter, Megan R. Kiedrowski, Jarrod W. Barnes, Stefanie Kricktotal and phospho-anti PLCγ along with rabbit total and phospho-anti ERK (Cell Signaling Technologies, 2822S, 8713S, 4695S, and 9101S, respectively). After 3 washes with TBST, membranes were incubated with goat-anti-rabbit

(7) Treating solid tumors with TCR-based chimeric antigen receptor targeting extra domain B-containing fibronectinJournal for ImmunoTherapy of CancerAugust 16, 2023Zhijie Zhang, Chang Liu, Muhan Wang, Rongcheng Sun, Zhe Yang, Zhen Hua, Yushuang Wu, Mengting Wu, Hang Wang, Wen Qiu, et al.(ab68235,Abcam), anti-LCK (2657, Cell Signaling Technology), anti-pLCK-Y394 (AP0182, ABclonal), anti-PLCγ (2822, Cell Signaling Technology), anti-pPLCγ (2821, Cell Signaling Technology), anti-NFATc1 (5861, Cell Signaling Technology

(8) Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signalingNature communicationsJune 22, 2023Nunes-Santos CJ, Kuehn H, Boast B, Hwang S, Kuhns DB, Stoddard J, Niemela JE, Fink DL, Pittaluga S, Abu-Asab M, et al.anti-phospho-PLCγ1 (Tyr783) (Cell Signaling Technology, Cat. 14008); anti- PLCγ1 (Cell Signaling Technology, Cat. 2822); anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (Cell Signaling Technology, Cat. 4377); anti-p44/42 MAPK (Erk1/2

(9) Jujuboside B suppresses angiogenesis and tumor growth via blocking VEGFR2 signaling pathwayHeliyonJune 7, 2023Pan Zhang, Xing Lai, Mao-Hua Zhu, Jiangpei Shi, Hong Pan, Yanhu Huang, Run-Jie Guo, Qin Lu, Chao Fang, Mei ZhaoLysis Buffer were obtained from Sangon Biotech. Anti-VEGFR2 (#2479), anti-pVEGFR2 (#2478), anti-PLCγ1 (#2822), anti-pPLCγ1 (#8713), anti-FAK (#3285), anti-pFAK (#8556), anti-Src (#2108), anti-pSrc (#59548), anti-Akt

(10) TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responsesCancer Immunology, ImmunotherapyJune 1, 2023Rebecca Harris, Mahinbanu Mammadli, Shannon Hiner, Liye Suo, Qi Yang, Jyoti Misra Sen, Mobin Karimi(Cell Signaling Technology # 45,533), ITK (Thermo Fisher PA5-49,363), PLCγ1 (Cell Signaling Technology #2822), ERK1-2 (Cell Signaling Technology #9107), JAK 2(Cell Signaling Technology # 3230), JAK3 (Cell Signaling Technology

(11) SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferationBMC molecular and cell biologyMay 16, 2023Wang K, Papadopoulos N, Hamidi A, Lennartsson J, Heldin CH.USA). The antibodies recognizing phospho-PDGFRα (pY849, #3170), phospho-PLCγ1 (pTyr783, #2821), PLCγ1 (#2822), phospho-STAT3 (pTyr705, D3A7, #9145), STAT3 (79D7, #4904), phospho-Akt (pSer473, D9E, #4060), Akt

(12) The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβInternational Journal of Molecular SciencesApril 24, 2023Niki Sarri, Natalia Papadopoulos, Johan Lennartsson, Carl-Henrik Heldinp44/p42 MAPK (Erk1/2, 137F5, #4695), phosphorylated p44/p42 Erk1/2 MAPK (pThr202/pThr204, #9101), PLCγ1 (#2822), phosphorylated PLCγ1 (pTyr783, #2821), STAT3 (79D7, #4904), phosphorylated STAT3 (pTyr705, D3A7, #9145)

(13) c-Abl Tyrosine Kinase Is Required for BDNF-Induced Dendritic Branching and GrowthInternational Journal of Molecular SciencesJanuary 18, 2023América Chandía-Cristi, Nicolás Stuardo, Cristian Trejos, Nancy Leal, Daniela Urrutia, Francisca C. Bronfman, Alejandra Álvarez Rojasanti-phospho-c-Abl (Tyr 412) (Sigma, #cat C5240), anti-PLC-γ (Cell Signaling, Danvers, MA, USA; #cat 2822), anti-phospho-PLC-γ (Tyr 783) (Cell Signaling, #cat 2821), anti-AKT (Cell Signaling, #cat 9272), anti-phospho-AKT

(14) Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosisJournal of Experimental MedicineJanuary 2, 2023Masato Ogishi, Rui Yang, Rémy Rodriguez, Dominic P. Golec, Emmanuel Martin, Quentin Philippot, Jonathan Bohlen, Simon J. Pelham, Andrés Augusto Arias, Taushif Khan, et al.antibodies. The following antibodies were used for immunoblotting: anti-PLCγ1 polyclonal antibody (Cat: 2822, 1:1,000; Cell Signaling Technology, room temperature for 1 h), anti-phospho-PLCγ1 (Y783; Cat: 2821,

(15) Kinetic proofreading through the multi-step activation of the ZAP70 kinase underlies early T cell ligand discriminationNature immunologySeptember 1, 2022Voisinne G, Locard-Paulet M, Froment C, Maturin E, Menoita MG, Girard L, Mellado V, Burlet-Schiltz O, Malissen B, Gonzalez de Peredo A, et al.anti-PLCγ1-pY783 (Cell Signaling Technology, catalog no. 2821), anti-PLCγ1 (Cell Signaling Technology, catalog no. 2822), anti-LAT-pY220 (Cell Signaling Technology, catalog no. 20172, clone E3S5L), anti-LAT-pY255 (Cell Signaling Technology

(16) Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healingCell reportsAugust 16, 2022Yao L, Rathnakar BH, Kwon HR, Sakashita H, Kim JH, Rackley A, Tomasek JJ, Berry WL, Olson LE.RRID:AB_329827 Rabbit anti-Akt (S473),Cell Signaling,Cat# 4051; RRID:AB_331158 Rabbit anti-PLCγ,Cell Signaling,Cat# 2822; RRID:AB_2163702 Rabbit anti-p-PLCγ (Y783),Cell Signaling,Cat# 14008; RRID:AB_2728690 Rabbit anti-βTubulin,Cell Signaling

(17) Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonizationDevelopmental cellMay 9, 2022Moy RH, Nguyen A, Loo JM, Yamaguchi N, Kajba CM, Santhanam B, Ostendorf BN, Wu YG, Tavazoie S, Tavazoie SF.p52,Millipore,Cat# 05-361; RRID: AB_309692 Rabbit polyclonal anti-PLCG1,Cell Signaling Technology,Cat# 2822; RRID: AB_2163702 Rabbit polyclonal anti-INPP5A,Proteintech,Cat# 21723-1-AP; RRID: AB_10734438 Rabbit

(18) 3D-organoid culture supports differentiation of human CAR⁺ iPSCs into highly functional CAR T cellsCell stem cellApril 7, 2022Wang Z, McWilliams-Koeppen HP, Reza H, Ostberg JR, Chen W, Wang X, Huynh C, Vyas V, Chang WC, Starr R, et al.D25A9) RRID:AB_10890863 "Anti-human, -rat, -mouse PLCγ1",Cell Signaling Technology,"Polyclonal, Cat# 2822, RRID:AB_2163702" "Anti-human, -mouse phospho-Zap-70 (Tyr319)/Syk (Tyr352)",Cell Signaling Technology,(clone

(19) FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse modelThe Journal of experimental medicineApril 4, 2022Cornille M, Moriceau S, Khonsari RH, Heuzé Y, Loisay L, Boitez V, Morice A, Arnaud E, Collet C, Bensidhoum M, et al.(catalog number 2821; 1:1,000 dilution; Cell Signaling), a polyclonal anti-PLCγ1 antibody (catalog number 2822; 1:1,000 dilution; Cell Signaling), a polyclonal anti-phospho-STAT3 antibody (catalog number 9131; 1:1,000

(20) Coronin 1A facilitates calcium mobilization and promotes astrocyte reactivity in HIV‐1 neuropathogenesisFASEB BioAdvancesApril 1, 2022Hriday Shanker Pandey, Rishabh Kapoor, Bindu, Pankaj Seth(Cell signaling, 1:1000, Cat# 2821S, RRID:AB_330855), rabbit anti‐PLCγ1 (Cell signaling, 1:1000, Cat# 2822S, RRID:AB_2163702), rabbit anti‐GFAP (Dako, 1:20000, Cat# Z0334, RRID:AB_10013382). Blots were washed

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PLCgamma1 Antibody

PLCgamma1 Antibody from Cell Signaling Technology

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Cell Signaling Technology

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PLCgamma1 Antibody from Cell Signaling Technology

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