Anti-Lrp2 / Megalin antibody ab76969 from Abcam

Product Specs
ItemAnti-Lrp2 / Megalin antibody
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab76969
Quantity200 UL
ClonalityPolyclonal
ApplicationsImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Antibody TypePrimary
Conjugate/TagUnconjugated
IsotypeIgG
HostRabbit
Concentration0.1 mg/ml
Gene NameLRP2
ReactivityHuman, Mouse
TargetLrp2 / Megalin

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosisiScienceOctober 20, 2023Hao Zhang, Zebin Deng, Yilong Wang, Xiaoping Zheng, Lizhi Zhou, Shu Yan, Yinhuai Wang, Yingbo Dai, Yashpal.S. Kanwar, Fei Dengab134064; 1:1 000), anti–ASC (proteintech, catalog 10500-1-AP; 1:200), and anti–Megalin (Abcam, catalog ab76969; 1:500). For quantification, the fluorescence density of the sections was determined by ImageJ software. Morphological

(2) Lipocalin 2 receptors: facts, fictions, and mythsFront ImmunolAugust 11, 2023Sarah K. Schröder, Natalie Gasterich, Sabine Weiskirchen, Ralf Weiskirchenfrom Bioss (Woburn, MA). Abcam presently offers seven different unconjugated antibodies against LRP2 (#ab76969, #ab309086, #ab309087, #ab236244, #ab223754, #ab101011, and #ab56014) from which six are recommend for immunohistochemistry

(3) Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorptionFrontiers in PharmacologyJuly 7, 2023Rodrigo A. S. Peres, Diogo B. Peruchetti, Rodrigo P. Silva-Aguiar, Douglas E. Teixeira, Carlos P. Gomes, Christina M. Takiya, Ana Acacia S. Pinheiro, Celso Caruso-NevesPaulo, SP, Brazil). Rapamycin was purchased from Pfizer (Itapevi, SP, Brazil). Polyclonal Lrp2/megalin (ab76969) and monoclonal albumin (ab207327) antibodies were purchased from Abcam (Cambridge, MA, United States).

(4) Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American MenCancer Research CommunicationsMarch 3, 2023Jason Garcia, Kirsten D. Krieger, Candice Loitz, Lillian M. Perez, Zachary A. Richards, Yves Helou, Steve Kregel, Sasha Celada, Clementina A. Mesaros, Maarten Bosland, et al.antigen retrieval (10 mmol/L sodium citrate, 0.05% Tween 20, pH 6), and stained with anti-megalin (1:500; ab76969, Abcam) overnight at 4°C. A rabbit secondary antibody HRP/DAB kit was used for visualization with hematoxylin

(5) Structures of LRP2 reveal a molecular machine for endocytosisCellFebruary 6, 2023Andrew Beenken, Gabriele Cerutti, Julia Brasch, Yicheng Guo, Zizhang Sheng, Hediye Erdjument-Bromage, Zainab Aziz, Shelief Y. Robbins-Juarez, Estefania Y. Chavez, Goran Ahlsen, et al.presence of LRP2 in washed membrane was confirmed by Western blot with anti-LRP2 antibody (Abcam, #ab76969). After the final wash, membrane was solubilized in 1.6% β-octylglucoside (OG) (Research Products International,

(6) Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null miceMolecular therapy. Methods & clinical developmentDecember 8, 2022Yadav MK, Yoo KW, Atala A, Lu B.from Proteintech (16922-1-AP, 1:1,000, Rosemont, IL), megalin rabbit polyclonal antibody from Abcam (ab76969, Boston, MA), and GFP antibody was from Cell Signaling Technology (Danvers, MA, cat. no. 2555S). HRP-conjugated

(7) SARS-CoV-2 spike protein inhibits megalin-mediated albumin endocytosis in proximal tubule epithelial cellsBiochimica et biophysica acta. Molecular basis of diseaseDecember 1, 2022Silva-Aguiar RP, Teixeira DE, Peruchetti DB, Florentino LS, Peres RAS, Gomes CP, Marzolo MP, Rocco PMR, Pinheiro AAS, Caruso-Neves C.anti-HA antibody (HA.11) was purchased from Covance (Princeton, NJ, USA). Polyclonal rabbit anti-megalin (ab76969), monoclonal rabbit anti-ACE2 (ab108252) and monoclonal mouse anti-aquaporin 1 (AQP1) (ab9566) antibodies

(8) Extended longevity geometrically-inverted proximal tubule organoidsBiomaterialsNovember 1, 2022Eric Parigoris, Ji-Hoon Lee, Amy Yunfan Liu, Xueying Zhao, Shuichi Takayamaantibodies were prepared in 1% BSA in PBS solutions at the following dilutions: rabbit anti-megalin (Abcam #ab76969, 1:500 dilution), mouse anti-aquaporin-1 (Santa Cruz #sc-32737, 1:200 dilution), mouse anti-ezrin/villin-2

(9) Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysisNature CommunicationsOctober 30, 2022Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Haojia Wu, Kohei Omachi, Nicolas Ledru, Parker C. Wilson, Andrew J. King, N. Eric Olson, Marvin G. Gunawan, et al.1:100), Anti-VCAM1 (Abcam; ab134047; 1:200), Anti-Cubilin (R&D Systems AF3700; 1:200), Anti-LRP2 (Abcam, ab76969; 1:200)] and incubated overnight in a humidifier chamber at 4 °C. The next day, slides were quickly

(10) A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell CarcinomaCancer discoveryOctober 5, 2022Rappold PM, Vuong L, Leibold J, Chakiryan NH, Curry M, Kuo F, Sabio E, Jiang H, Nixon BG, Liu M, et al.Aqp1 #Ab15080 Abcam 1:500, c-myc clone Y69 Abcam 1:100, CA-9 clone EPR23055-5 Abcam 1:500, Megalin #Ab76969 Abcam 1:1000, Glut1 #Ab14683 Abcam 1:500, Synaptophysin clone YE269 Abcam 1:400, Chromogranin-A clone

(11) Vascular endothelial growth factor from retinal pigment epithelium is essential in choriocapillaris and axial length maintenancePNAS NexusSeptember 1, 2022Zhang Y, Jeong H, Mori K, Ikeda SI, Shoda C, Miwa Y, Nakai A, Chen J, Ma Z, Jiang X, et al.ThermoFisher Scientific I21413), rat anti-ZO-1 (1:125; Invitrogen 14,977,682), rabbit anti-Lrp2 (1:1000; Abcam ab76969), Rabbit Collagen I antibody (1:500; Novus NB600-408). Images were obtained using a confocal microscope

(12) Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathyJCI insightAugust 22, 2022Chen J, Luo P, Wang C, Yang C, Bai Y, He X, Zhang Q, Zhang J, Yang J, Wang S, et al.antibodies against CD4 (Abcam, ab183685), CD8 (Abcam, ab217344), Aqp1 (Abcam, ab168387), Lrp2 (Abcam, ab76969), Ki67 (Abcam, ab15580), CD86 (Abcam, ab220188), α-SMA (Proteintech, 14395-1-AP), CD86 (Abcam, ab220188),

(13) EPO synthesis induced by HIF‐PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non‐injured nephron segments in murine kidney fibrosisActa Physiol (Oxf)August 1, 2022Hanako Kobayashi, Olena Davidoff, Shiuli Pujari‐Palmer, Malin Drevin, Volker H. Haaseantibody (AF1817 at 1:100 dilution, R&D Systems, Minneapolis, MN) and anti-megalin polyclonal antibody (ab76969 at 1:000 dilution, Abcam, Cambridge, UK) were used. RNA fluorescence in situ hybridization. Acta2,

(14) CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomasInternational journal of oncologyAugust 1, 2022Slominski AT, Brożyna AA, Kim TK, Elsayed MM, Janjetovic Z, Qayyum S, Slominski RM, Oak ASW, Li C, Podgorska E, et al.min. The sections were incubated 30 min at room temperature with anti-Lrp2/Megalin antibody (cat. no. ab76969; Abcam) or overnight with other antibodies (anti-VDR; clone 9A7; cat. no. MA1-710) or anti-RORγ and

(15) Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular functionNature communicationsApril 4, 2022Hinden L, Ahmad M, Hamad S, Nemirovski A, Szanda G, Glasmacher S, Kogot-Levin A, Abramovitch R, Thorens B, Gertsch J, et al.5% goat serum (VE-S-1000, Vector Laboratories). The sections were stained with a Rabbit anti-LRP2 (ab76969, Abcam, 1:1000) antibody, followed by incubation with a Goat anti-Rabbit-AF488 antibody (ab150077, Abcam,

(16) Snapshots of nascent RNA reveal cell- and stimulus-specific responses to acute kidney injuryJCI insightMarch 22, 2022Shen TH, Stauber J, Xu K, Jacunski A, Paragas N, Callahan M, Banlengchit R, Levitman AD, Desanti De Oliveira B, Beenken A, et al.mouse Kim-1 (1:200; R&D Systems, catalog AF1817) and rabbit anti mouse Megalin (1:400; Abcam catalog ab76969) (Supplemental Table 13). Fluorescent secondary antibodies, Alexa Fluor 594–AffiniPure F(ab′)2 Fragment

(17) Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem cells in a dynamic culture systemCell proliferationMarch 1, 2022Ngo TTT, Rossbach B, Sébastien I, Neubauer JC, Kurtz A, Hariharan K.(WT1) (sc192, SCBT), AQP1 (20333–1‐AP, Proteintech), Na⁺/K⁺‐ATPase (ab76020, Abcam), Megalin/LRP2 (ab76969, Abcam), SGLT2 (ab58298, Abcam), LTL (FL‐1321, Vector Laboratories), organic cation transporter 2 (OCT2)

(18) Identification of RPS7 as the Biomarker of Ferroptosis in Acute Kidney InjuryBioMed research internationalJanuary 1, 2022Zhang H, Liu X, Zhou L, Deng Z, Wang Y.fluorescence microscopy. The primary antibodies used in our study were anti-Megalin (Abcam, catalog ab76969; 1 : 500) and anti-RPS7 (Proteintech, catalog 14491-1-AP; 1 : 500). 2.11. Immunohistochemistry Staining 4-μm

(19) Elevated Neutrophil Gelatinase-Associated Lipocalin Is Associated With the Severity of Kidney Injury and Poor Prognosis of Patients With COVID-19Kidney International ReportsDecember 1, 2021Katherine Xu, Ning Shang, Abraham Levitman, Alexa Corker, Satoru Kudose, Andrew Yaeh, Uddhav Neupane, Jacob Stevens, Rosemary Sampogna, Angela M. Mills, et al.LRP2 and UMOD by immunoblot with SDS-PAGE (Bio-Rad Laboratories), rabbit anti-LRP2 (1:1000, Abcam, ab76969), sheep anti-UMOD (1:2000, Meridian Life Science, K90071C), and polyclonal secondary antibodies conjugated

(20) Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in miceKidney360September 1, 2021Ranea-Robles P, Portman K, Bender A, Lee K, He JC, Mulholland DJ, Argmann C, Houten SM.following antibodies: anti-KIM-1 (AF1817, RD Systems), anti-SOX-9 (NBP1–8551, Novus Bio), anti-LRP2 (ab76969, Abcam), anti-SGLT1 (ab14685, Abcam), biotinylated-LTL (B-1325, Vector Laboratories), anti-EHHADH (GTX81126,

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Anti-Lrp2 / Megalin antibody from Abcam

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Anti-Lrp2 / Megalin antibody from Abcam

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