The Anti SQSTM1/A170/p62, Rabbit Antibody from FUJIFILM Wako Chemicals U.S.A. Corp is a Rabbit Polyclonal antibody. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Anti SQSTM1/A170/p62, Rabbit Antibody has been validated for the following applications: Immunocytochemistry, Immunohistochemistry, and Western Blot.
Description
Sequestosome 1 (SQSTM1)/A170 (mouse)/p62 (human)/ZIP (rat) a ubiquitin-binding protein, expresses oxidative stress-dependently. Abnormality of SQSTM1 leads to bone metabolic disorder, obesity and Type II diabetes. SQSTM1 was reported to bind LC3, which regulates autophagosome formation. The protein has attracted the attention of researchers because it is believed to induce a protein from ubiquitin-proteosome system (UPS) to the lysosome-dependent macroautophagy (autophagy) system, which are two major intracellular pathways for protein degradation. Wako launched the mouse SQSTM1 (A170) rabbit antiserum, which is applicable to Western blot, immunohistochemistry and immunofluorescence