Fig 1: Notch3 deletion reduces CD68 positive macrophage invasion(A and B) Serial sessions from HIVAN patient biopsy immunostained for the presence of CD68 and Notch3. Note the presence of CD68 positive cells in and around glomerulus, the same areas were also labelled bright for the presence of Notch3 (arrows, Fig:5B). (C, D and E) Paraffin sections from kidneys of WT, N3KO, Tg26, Tg-N3KO mice, labeled for immune cell markers: CD68, FoxP3 and CD8, respectively). (F, G and H) Quantification of CD68, FoxP3 and CD8 positive cells from Tg26 and Tg-N3KO mice, blindly assessed in Tg26 (n=5) and Tg-N3KO (n=5) kidneys. Each dot represents percent positive cells from the entire kidney where inflammatory invasions were prominent (*P<0.05), (Scale bar: 50μm).