Fig 1: (A) Morphological diagnostic immunochemistry image with hematoxylin and eosin (H&E) staining of the right posterior upper lung nodule biopsy. Circumscribed tumor adjacent to normal tissue (top left corner) showing spindle to sclerotic tumor. The round spaces are thought to be entrapped/residual alveolar spaces. Scale bar, 300 µM. (B) H&E close-up showing spindle to sclerotic tumor. Scale bar, 200 µM. (C) Immunohistochemistry (IHC) staining for CD24. Scale bar, 300 µM. (D) IHC staining for cleaved NOTCH1. Scale bar, 100 µM. (E) IHC staining for JAGGED1 (upstream of NOTCH). Scale bar, 300 µM. (F) IHC staining for HEY1 (downstream from NOTCH). Scale bar, 100 µM.