Fig 1: Region-specific low expression of oligodendrocyte and myelin-associated proteins. (A) Heatmap of myelin-associated proteins in CA1, CA3 and the EC regions. The Color intensity represents protein abundance. (B) Representative image of IHC staining of MBP and CNP in the EC region of normal, Pre-AD and AD specimens. Scale bar: 50 µm. (C and D) Expression intensity of MBP and CNP proteins in each area in normal, Pre-AD and AD specimens. The intensity was calculated based on grayscale values using Image-Pro Plus 6.0 software. Mean IOD: mean integrated optical density. One-way ANOVA is used to compare the mean IOD among normal, pre-AD and AD group in each brain region. There is no significant difference among normal, pre-AD and AD group in CA1–CA4/DG regions. The p-value of CA1–CA4/DG region is shown in Table S6. *p < 0.05
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