Fig 1: Case description. (A) Family map of the boy, the arrow shows the affected boy, the family’s probate, whose mother’s urine test indicated hematuria, with the same type of genetic mutation. (B) Renal pathological examination of this boy. 1: light microscopy: minor glomerulus lesions; 2: immunofluorescence of a5 chain was negative; 3: immunofluorescence of a2 chain was positive (×400). (C) First-generation sequencing confirmed the presence of COL4A5 gene c.1844G>C mutation in the children, with normal genotype in his father and heterozygous mutation in his mother. *, P<0.05.