Fig 1: KCNE4 vitamin D response element (VDRE) and Kv7 channel expression in Vdr knockout mice. (A) Predicted VDRE in the promoter region of the KCNE4 gene conserved between humans and mice. (B) Vitamin D receptor (VDR) and retinoid X receptor (RXR) protein interface signatures and the estimated binding specificities in the VDRE of the KCNE4 gene as sequence logo provided by 3D-footprint. Larger letters indicate greater affinity, and smaller letters indicate the allowable variability. (C–E) Averaged densitometric protein expression of (C) Kv7.1, (D) Kv7.4, and (E) KCNE4. Results are means ± standard error of the mean (n = 6–7 animals). * p < 0.05 vs. WT using a t-test. Original Western Blotting data can be found in Figure S1.