Fig 1: The mechanism underlying synaptic plasticity induced by environmental enrichment. The increased expression of synaptic vesicle-associated proteins leads to neural plasticity due to the activation of synaptic proteins and synaptic vesicle fusion. Among the presynaptic active zone proteins, Piccolo interacts with other presynaptic active zone proteins to organize a super-molecular complex. SV2B is involved in exocytosis. Rabphilin-3A regulates exocytosis and endocytosis in the presynaptic zone. The increased expression of these proteins promotes their interactions with other proteins in the presynaptic active zone, may regulate synaptic vesicle activity and induce synaptic plasticity. These upregulated presynaptic proteins may be responsible for improved locomotor performance.