Fig 1: Loss of function of JNK3 promotes dysregulation of normal metabolic function. Protein levels were detected. A Endoplasmic reticulum-related [PERK, P-PERK (Thr980), EIF2, P-EIF2 (Ser51), ATF4, IRE1a and P-IRE1a (Ser724)] and B PTP1B and P-PTP1B (Ser50). Results were represented as bar graphs and differences between groups was analyzed using ANOVA and Tukey’s (n = 4 per experimental group). Significance was represented as follows: *p < 0.05, **p < 0.01 and ***p < 0.001