Fig 1: Integrin inhibition diminishes microstructure motility in HA-based hydrogels. Angular velocities (?) of hS/PC microstructures were plotted with respect to size (A–D). The ? of hS/PC structures treated with siRNA targeting ß1 integrin demonstrated an 84% mean reduction in ? compared to its control (p < 0.0001). Organized hS/PC structures treated with integrin blocking antibody CD49a resulted in a 73% reduction in ? when compared to its non-blocking CD49a control (p < 0.0001) (E). The ? of hS/PC structures treated with scrambled siRNA and non-blocking CD49a control groups were not significantly different from each other, p = 0.23.