Description
Product Characteristics: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions.,C/EBP-beta,IL6DBP,NF-IL6,TCF5,CEBP beta,CEBPB,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Cell Adhesion,Wnt/β-Catenin Signaling Pathway,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,Cardiovascular,Heart,Hypertrophy,CEBPB
Target Information: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]