Fig 1: Annexin A6 (ANXA6) is upregulated in gemcitabine-resistant cell-derived exosomes.A The heatmap presents differentially expressed proteins between two pairs of exosomes (231-S-exo and 231-R-exo, 231-HM-S-exo and 231-HM-R-exo). B The Venn diagram of overlap between 231-R-exo/231-S-exo and 231-HM-R-exo/231-HM-S-exo. C, D TFPI, COL8A1, annexin A1, ANXA6 and HLA-B protein levels in MDA-231, MDA-231-R, MDA-231-HM, and MDA-231-HM-R cells and in 231-S-exo, 231-R-exo, 231-HM-S-exo, and 231-HM-R-exo. E The changes of ANXA6 in MDA-231 and MDA-231-HM cells treated with PBS, sensitive cell-derived exosomes (231-S-exo or 231-HM-S-exo), or resistant cell-derived exosomes (231-R-exo or 231-HM-R-exo). All the experiments were repeated three times, and the representative results are presented.