Anti-BRCA1 antibody [MS110] ab16780 from Abcam

Product Specs
ItemAnti-BRCA1 antibody [MS110]
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab16780
Quantity10 UG, 100 UG
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunohistochemistry (Frozen sections), Immunoprecipitation, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunohistochemistry (Frozen sections), Immunoprecipitation
Conjugate/TagUnconjugated
HostMouse, Nude mouse
Antibody TypePrimary
ClonalityMonoclonal
CloneMS110
Research AreaEpigenetics
Gene NameBRCA1
ReactivityHuman
TargetBRCA1

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Arsenite Impairs BRCA1-Dependent DNA Double-Strand Break Repair, a Mechanism Potentially Contributing to Genomic InstabilityInternational Journal of Molecular SciencesSeptember 21, 2023Tizia Matthäus, Sandra Stößer, Hatice Yasemin Seren, Vivien M. M. Haberland, Andrea Hartwigsc-515841 (E-10)), anti-DNA-PKcs Phospho (Thr2609) antibody (Biolegend 612902), anti-BRCA1 antibody (Abcam ab16780), anti-Rad51 antibody (Abcam ab63801) or anti-Rad54 antibody (Santa Cruz sc-374598 (F-11)) for one hour

(2) KMT2C expression and DNA homologous recombination repair factors in lung cancers with a high-grade fetal adenocarcinoma componentTranslational Lung Cancer ResearchAugust 30, 2023Masaki Suzuki, Rika Kasajima, Tomoyuki Yokose, Eigo Shimizu, Seira Hatakeyama, Kiyoshi Yamaguchi, Kazuaki Yokoyama, Kotoe Katayama, Rui Yamaguchi, Yoichi Furukawa, et al.1:100), anti-ATR (LSBio Cat# LS B4288-50, RRID: AB_10945735, dilution 1:50), anti-BRCA1 (Abcam Cat# ab16780, RRID: AB_2259338, dilution 1:200), anti-BRCA2 (Sigma-Aldrich Cat# HPA026815, RRID: AB_10602692, dilution

(3) RAD54L regulates replication fork progression and nascent strand degradation in BRCA1/2-deficient cellsbioRxiv : the preprint server for biologyJuly 26, 2023Uhrig ME, Sharma N, Maxwell P, Selemenakis P, Wiese C.Cell Signaling; 1:6,000) α-FBH1 (sc-81563; 1:100), α-BRCA2 (OP95; EMD Millipore; 1:500), α-BRCA1 (MS110; ab16780; Abcam; 1:50), α-PCNA (sc-25280; Santa Cruz Biotechnology; 1:1,000), α-NUCKS1 ([41]; 1:10,000). HRP-conjugated

(4) LncRNA ANRIL promotes HR repair through regulating PARP1 expression by sponging miR-7-5p in lung cancerBMC CancerFebruary 8, 2023Zhipeng Du, Fangxiao Zhang, Lei Liu, Hui Shen, Tingting Liu, Jing Jin, Nanxi Yu, Zhijie Wan, Hang Wang, Xuguang Hu, et al.Triton X-100 on ice for 15 min. After blockage, cells were stained with anti-BRCA1 antibody (1:200, ab16780, Abcam) or anti-Rad51 antibody (1:250, ab133534, Abcam) and then with the secondary antibody. Cellular

(5) Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination RepairAdvanced ScienceJanuary 1, 2023Xin Peng, Shaolu Zhang, Yingying Wang, Zhicheng Zhou, Zixiang Yu, Zhenxing Zhong, Liang Zhang, Zhe‐Sheng Chen, Francois X. Claret, Moshe Elkabets, et al.γ‐H2AX (Abcam, ab81299), BRCA1 (Cell Signaling Technology, 14823, for Western blot), BRCA1 (Abcam, ab16780, for IHC), BRCA2 (Abcam, ab216972), RAD51 (Abcam, 133534), Ki‐67 (Cell Signaling Technology, 9027),

(6) XPF activates break-induced telomere synthesisNature communicationsOctober 2, 2022Guh CY, Shen HJ, Chen LW, Chiu PC, Liao IH, Lo CC, Chen Y, Hsieh YH, Chang TC, Yen CP, et al.cat#MABC545, dilution 1:1,000), γH2AX (Cell Signaling, cat#9718 T, dilution 1:1,000), BRCA1 (Abcam, cat#ab16780, dilution 1:1,000), SLX4 (Bethyl Laboratories, cat#A302-269A, dilution 1:1,000), CSB (Bethyl Laboratories,

(7) A human breast atlas integrating single-cell proteomics and transcriptomicsDevelopmental CellJune 1, 2022G. Kenneth Gray, Carman Man-Chung Li, Jennifer M. Rosenbluth, Laura M. Selfors, Nomeda Girnius, Jia-Ren Lin, Ron C.J. Schackmann, Walter L. Goh, Kaitlin Moore, Hana K. Shapiro, et al.(165Ho, CyTOF)",Cell Signaling Technology,Cat#2524; RRID: AB_331743 "BRCA1 (169Tm, CyTOF)",Abcam,Cat# ab16780; RRID: AB_2259338 "HLA-A/B/C (167Er, CyTOF)",Biolegend,Cat#311402; RRID: AB_314871 "H3K27me3 (175Lu,

(8) Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient StratificationCancer researchApril 15, 2022Pellegrino B, Herencia-Ropero A, Llop-Guevara A, Pedretti F, Moles-Fernández A, Viaplana C, Villacampa G, Guzmán M, Rodríguez O, Grueso J, et al.10802-1-AP, 1:400), mouse anti-BRCA1 (Santa Cruz Biotechnology sc-6954, 1:50), mouse anti-BRCA1 (Abcam ab16780, 1:200), mouse anti-phospho-H2AX (Millipore #05-636, 1:200). Goat anti-rabbit Alexa fluor 568 (Invitrogen;

(9) 2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneityCell reportsJanuary 11, 2022Kusi M, Zand M, Lin LL, Chen M, Lopez A, Lin CL, Wang CM, Lucio ND, Kirma NB, Ruan J, et al.(Lys79),Boster Biological Technology,Cat# CI1046 Mouse monoclonal anti-BRCA1 (Clone MS110),Abcam,Cat# ab16780 Mouse monoclonal anti-MSH2 (Clone 3A2B8C),Abcam,Cat# ab52266 Mouse monoclonal anti-XRCC2 (Clone EPR5149),Abcam,Cat#

(10) Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagyJournal of Experimental & Clinical Cancer ResearchDecember 1, 2021Xin Peng et al.12712), γH2AX (Abcam, ab81299), BRCA1 (Cell Signaling Technology, 14823, for Western blot), BRCA1 (Abcam, ab16780, for IHC), BRCA2 (Abcam, ab216972), Rad51 (Abcam, 133534), phospho-ATM (S1981, Abcam, ab81292), Ki-67

(11) Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress responseeLifeJune 18, 2021McMahon KA, Stroud DA, Gambin Y, Tillu V, Bastiani M, Sierecki E, Polinkovsky ME, Hall TE, Gomez GA, Wu Y, et al.sc-642, RRID:AB_630944, WB 1:500, IF 1:100, PLA 1:100), mouse anti-BRCA1 MS110 antibody (Abcam, Cat# ab16780, RRID:AB_2259338, WB 1:1000, IF 1:100, PLA 1:100), mouse-anti-BRCA1 D-9 antibody (Santa Cruz, Cat# sc-6964,

(12) SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylationCell ReportsMarch 30, 2021Elizabeth V. Minten, Priya Kapoor-Vazirani, Chunyang Li, Hui Zhang, Kamakshi Balakrishnan, David S. YuPrism 7 using a one-sample t test. Antibodies and reagents The following antibodies were used: BRCA1 (ab16780, Abcam: 1/1000 for western and 1/200 for IF) and (sc-6954, Santa Cruz Biotechnology: 1/300 for western).

(13) Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosisCommunications biologyOctober 23, 2020Chai Q, Lu Z, Liu Z, Zhong Y, Zhang F, Qiu C, Li B, Wang J, Zhang L, Pang Y, et al.immunohistochemical staining), anti-MMP8 (#sc-514803, Santa Cruz, 1:100 for immunohistochemical staining), anti-BRCA1 (#ab16780, Abcam, 1:100 for immunohistochemical staining), anti-PCNA (#sc-25280, Santa Cruz, 1:100 for immunohistochemical staining

(14) IGF1R Axis Inhibition Restores Dendritic Cell Antitumor Response in Ovarian CancerTranslational OncologyAugust 1, 2020Lina Somri-Gannam, Shilhav Meisel-Sharon, Shay Hantisteanu, Gabriel Groisman, Ofer Limonad, Mordechai Hallak, Ilan Bruchimused: IGF1R (sc-81167, Santa Cruz Biotechnology, Inc.), p53 (M7001, DAKO), Ki67 (M 7240, DAKO), BRCA1 (ab16780, Abcam), CD141 (ab109189, Abcam), and CD1c (ab156708, Abcam). Slides were then counterstained with hematoxylin

(15) Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cellsCell death & diseaseJuly 24, 2020Zhai B, Li Y, Kotapalli SS, Bacha J, Brown D, Steinø A, Daugaard M.Signaling Technology); ɣH2AX (05–636, MilliporeSigma, Oakville, Canada); cyclin A2 (ab16726, Abcam); BRCA1 (ab16780, Abcam); Rad51 (H8349, Santa Cruz Biotechnology); RPA32 (ab2175, Abcam); donkey anti-rabbit Alexa-Fluor

(16) Olaparib and enzalutamide synergistically suppress HCC progression via the AR‐mediated miR‐146a‐5p/BRCA1 signalingThe FASEB JournalApril 1, 2020Jie Zhao, Yin Sun, Hui Lin, Fuju Chou, Yao Xiao, Ren'an Jin, Xiujun Cai, Chawnshang Changby incubation with HRP-conjugated secondary antibody (Dako) for 60 min at room temperature. BRCA1 (ab16780, Abcam, Cambridge, MA), Ki67 (ab16667, Abcam) and cleaved caspase-3 (ab2302, Abcam) antibodies were

(17) DNA damage induced during mitosis undergoes DNA repair synthesisPloS oneJanuary 1, 2020Gomez Godinez V, Kabbara S, Sherman A, Wu T, Cohen S, Kong X, Maravillas-Montero JL, Shi Z, Preece D, Yokomori K, et al.laser. Scale bar = 10μ m. (E and F) BRCA1 immunostaining using two different antibodies. (E) BRCA1 ab16780 antibody (Abcam). (F) BRCA1 OP107 antibody (Calbiochem). (F-G) show the localization of BRCA1 and 53BP1

(18) Colocalization of BRCA1 with Tau Aggregates in Human TauopathiesBrain SciencesDecember 20, 2019Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi IwataCan Get Signal Solution 1 (Toyobo, Osaka, Japan) overnight at 4 ◦ C. Anti-BRCA1 (MS110; Abcam; Cat# ab16780; 1:1000), anti-human Tau (HT7; Thermo Fisher Scientific; Cat# MN1000; 1:2000), and anti-actin (C4; Merck Millipore

(19) Dynamically decreased miR-671-5p expression is associated with oncogenic transformation and radiochemoresistance in breast cancerBreast cancer research : BCRAugust 7, 2019Tan X, Li Z, Ren S, Rezaei K, Pan Q, Goldstein AT, Macri CJ, Cao D, Brem RF, Fu SW.vimentin (5741, 1:200 Cell Signaling), anti-rabbit E-cadherin (3195, 1:200, Cell Signaling), anti-BRCA1 (ab16780, 1:500, Abcam), Alexa Flour 568 goat anti-mouse IgG (1:500, Invitrogen), and Alexa Flour 568 goat anti-mouse

(20) Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradationCell Death & DifferentiationMay 1, 2019SeoYoung Kim, Hee Jin, Hang-Rhan Seo, Hae June Lee, Yun-Sil LeeSciences. Immunohistochemistry Immunohistochemistry was performed with the following antibodies: BRCA1 (ab16780, Abcam) or CTSS (sc-271619, Santa Cruz Biotechnology) and mouse anti-Ki-67 (M7248, Dako). Human breast cancer

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Anti-BRCA1 antibody [MS110] from Abcam

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Anti-BRCA1 antibody [MS110] from Abcam

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