Fig 1: Overexpression of IDO affected the MAPK/ERK pathway. Western blot assay was performed on the protein expression levels of (A) p-Raf-1, Raf-1, p-Mek1/2 Mek1/2 (B) p-Erk1/2 and (C) Erk1/2 in 16HBE cells treated with control, NC, DEX, NC+DEX, and IDO+DEX. *P<0.05, **P<0.01 vs. control, ^P<0.05, ^^P<0.01 vs. NC. IDO, indoleamine 2, 3-dioxygenase; MAPK, mitogen-activated protein kinase; ERK, extracellular regulated kinase; p-Raf-1, phosphorylated-v-raf-1 murine leukemia viral oncogene homolog 1; p-Mek1/2, phosphorylated-mitogen-activated protein kinase; NC, negative control; DEX, dexamethasone.
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