Fig 1: Effect of ITGB5 expression on MEK/ERK signaling protein expression levels in BXPC3 cells before and after irradiation. *p < 0.05, **p < 0.01, ****p < 0.0001. “ns”, Not Statistically.
Fig 2: The effect of ITGB5 on proliferation of pancreatic cancer cells in vitro by CCK8 (A, B) and colony formation assay (C-F). **p < 0.01, ***p < 0.001.
Fig 3: Effect of ITGB5 expression on DNA damage proteins expression levels in BXPC3 cells. (A, B) The effect of ITGB5 overexpression (A) and ITGB5 knockout (B) on ?-H2AX expression at different time points after irradiation in BXPC3 cells. (C) the effects of ITGB5 overexpression and knockout on DNA injury repair protein expression in BXPC3 cells before and after irradiation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
Fig 4: ITGB5 expression in pancreatic cancer cells by Western blot. (A) ITGB5 expression in normal pancreatic cell (HPDE6-C7) and pancreatic cancer cells (BXPC3, PANC-1, ASPC1). (B) verification of ITGB5 knockout, ITGB5 overexpression, and control PANC-1 cells. (C) Verification of ITGB5 knockout, ITGB5 overexpression, and control BXPC3 cells. **p < 0.01, ***p < 0.001.
Fig 5: Effect of ITGB5 expression on the cell-cycle distribution in BXPC3 cells irradiated by 6 Gy. (A) Results of cell cycle flow cytometry in BXPC3 cells; (B) The statistical analysis results of cell cycle in BXPC3 cells. ****p < 0.0001.
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