Acetyl-Histone H4 (Lys12) Antibody 2591S from Cell Signaling Technology

Product Specs
ItemAcetyl-Histone H4 (Lys12) Antibody
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number2591S
Quantity100 µl
ApplicationsW, IF-IC
ReactivityH, M, R, Mk
TargetH4 (Lys12) acetylate
ModificationsH4 (Lys12) acetylate
HostRabbit
NCBI Gene AliasesH4-16, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4FA, HIST1H4A
NCBI Full Gene NameH4 clustered histone 1
ClonalityPolyclonal
Research AreaChromatin Regulation / Nuclear Function
Molecular Weight11

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Cell Signaling Technology

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Assessing the contributions of intraspecific and environmental sources of infection in urban wildlife: Salmonella enterica and white ibis as a case studyJournal of The Royal Society InterfaceApril 9, 2019Daniel J. Becker, Claire S. Teitelbaum, Maureen H. Murray, Shannon E. Curry, Catharine N. Welch, Taylor Ellison, Henry C. Adams, R. Scott Rozier, Erin K. Lipp, Sonia M. Hernandez, et al.University, Bloomington, IN, USA DJB, 0000-0003-4315-8628; CST, 0000-0001-5646-3184; MHM, 0000-0002-2591-0794; SA, 0000-0001-9966-2773 Received: 30 August 2018 Accepted: 15 November 2018 Subject Category: Life

(2) Simvastatin Restores HDAC1/2 Activity and Improves Behavioral Deficits in Angelman Syndrome Model MouseFrontiers in molecular neuroscienceJanuary 1, 2019Kumar V, Joshi T, Vatsa N, Singh BK, Jana NR.BD Bioscience (611416). Rabbit monoclonal anti-H3(4499), anti-H3(K9) (9649), anti-H4(13919), anti-H4(K12) (2591) and anti-RAD23A; mouse monoclonal anti-HDAC1(5356) and anti-HDAC2(5113) were purchased from Cell Signaling Technology

(3) Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylationEuropean Journal of Medicinal ChemistryJune 25, 2018Thais Regina Ferreira de Melo et al.Hercules, CA) for 1 h and incubated with anti-acetyl-histone H4 (1:1000; Cell Signaling Technology,Cat# 2591 S) antibody at 4 C overnight. After washing three times, blots were incubated with T.R.F. Melo

(4) Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein BimCell Death & DiseaseJanuary 1, 2018Yanna Wu et al.2574), Ac-H3K9 (CST, no. 9671), Ac-H3K14 (CST, no. 7627), Ac-H3K27 (CST, no. 4353), Ac-H4K12 (CST, no. 2591), Ac-H4K5 (CST, no. 8647), Caspase 3 (CST, no. 9662), Caspase 6 (CST, no. 9762), Bim (CST, no. 3305),

(5) Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancerAmerican Journal of Physiology-Lung Cellular and Molecular PhysiologyDecember 1, 2016Isaac K. Sundar, Irfan Rahmanno. 2901), di-methyl-histone H3 (Lys79) (catalog no. 9757), acetyl histone H4 (Lys12) (catalog no. 2591), histone H3 (catalog no. 9715), and histone H4 (catalog no. 2592) antibodies were obtained from Cell Signaling

(6) Epigenetic stability in the adult mouse cortex under conditions of pharmacologically induced histone acetylationBrain Structure and FunctionNovember 1, 2016Jamie Benoit, Albert Ayoub, Pasko Rakic(Cell Signaling, cat # 4318S), or a 1:500 dilution of rabbit anti-AcH4Lys12 antibody (Cell Signaling, cat # 2591S), in 5 % milk TTBS overnight at 4 °C on a rocker table. The following day, after rinsing with TTBS,

(7) Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activityBioorganic & Medicinal ChemistryNovember 1, 2016Samantha M. Gromek, James A. deMayo, Andrew T. Maxwell, Ashley M. West, Christopher M. Pavlik, Ziyan Zhao, Jin Li, Andrew J. Wiemer, Adam Zweifach, Marcy J. Balunashistones (Acetyl-Histone H3 (K9) #9649, Acetyl-Histone H3 (K23) #8848, or Acetyl-Histone H4 (K12) #2591) from Cell Signaling Technologies (Danvers, MA). The JLA20 actin antibody was obtained from the University

(8) Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathwaysOncotargetJune 14, 2016Lee YS, Kim SY, Song SJ, Hong HK, Lee Y, Oh BY, Lee WY, Cho YB.

(9) Trichostatin A inhibits inflammation in phorbol myristate acetate-induced macrophages by regulating the acetylation of histone and/or non-histone proteinsMolecular Medicine ReportsJanuary 1, 2016QIAN ZHANG, FAN YANG, XUN LI, LUWEN WANG, XIAOGANG CHU, HONG ZHANG, ZUOJIONG GONGCell Signaling Technology, Inc.), anti‑H4 (cat. no. 2935; 1:1,000; Cell Signaling Technology, Inc.), anti‑AH4 (cat. no. 2591; 1:1,000; Cell Signaling Technology, Inc.), anti‑p65 (cat. no. 6956; 1:1,000; Cell Signaling Technology, Inc.),

(10) Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's diseaseNeurobiology of AgingDecember 1, 2015Diego Mastroeni, Elaine Delvaux, Jennifer Nolz, Yuyan Tan, Andrew Grover, Salvatore Oddo, Paul D. Coleman,Cell Signaling/9753 Total H4,Rabbit,1/1000,Cell Signaling/2935 Acetylated H4k12,Rabbit,1/1000,Cell Signaling/2591 Beta actin,Mouse,1/3000,Sigma/A1978 Lamin A,Mouse,1/2000,Sigma/SAB4200420 PHF-1,Mouse,1/1000,Gift

(11) Glycolytic metabolism influences global chromatin structureOncotargetFebruary 28, 2015Xue-Song Liu, John B. Little, Zhi-Min Yuan(Cell Signaling, #8647); H4K8Ac antibody (Cell Signaling, #2594); H4K12Ac antibody (Cell Signaling, #2591); Anti-βactin antibody (AC-15, Sigma); Anti-Hsp90 antibody (AC-16, Sigma) was used for western blot;

(12) Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memoryNature neuroscienceJuly 1, 2014Hait NC, Wise LE, Allegood JC, O'Brien M, Avni D, Reeves TM, Knapp PE, Lu J, Luo C, Miles MF, et al.(ab24834), H3K9ac (ab10812), H4K5ac (ab51997) and H2BK12ac (ab61228) (Abcam, 1:1,000 dilution); H4K12ac (2591), lamin a/c (2032), tubulin (2145), p-ERK1/2 (4372), HDAC3 (3949) and HDAC7 (2882) (Cell Signaling,

(13) Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in miceEuropean Respiratory JournalMay 1, 2014Y. Y. Sanders, James S Hagood, Hui Liu, Wei Zhang, Namasivayam Ambalavanan, Victor J ThannickalDiego, CA, USA). Anti-Bak (#12105), Bcl-xL (#2764), b-tubulin (#2128), H3Ac (#9671), H3 (#9715), H4Ac (#2591) and H4 (#2935) were obtained from Cell Signaling (Beverly, MA, USA). Anti-H3K9Ac (#61251) and H3K9Me3

(14) A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Panobinostat, an HDAC Inhibitor, Combined with Erlotinib in Patients with Advanced Aerodigestive Tract TumorsClinical Cancer ResearchMarch 15, 2014Jhanelle E. Gray et al.in FPB and in PBMCs by Western blot analysis using acetyl-histone H4 (Cell Signaling, Danvers, MA; 2591S) and β-actin (Sigma, St Louis, MO; A1978) antibodies, as previously described (16); β-actin was used

(15) Toxoplasma gondii Inhibits Gamma Interferon (IFN-γ)- and IFN-β-Induced Host Cell STAT1 Transcriptional Activity by Increasing the Association of STAT1 with DNAInfection and ImmunityFebruary 1, 2014Emily E. Rosowski, Quynh P. Nguyen, Ana Camejo, Eric Spooner, Jeroen P. J. SaeijGRA7 (33), histone H3 (Abcam, catalog no. 1791), acetyl-histone H4Lys12 (Cell Signaling, catalog no. 2591), and phospho-STAT6Tyr641 (Santa Cruz, catalog no. 11762-R) were used in immunofluorescence and Western blot

(16) Histone Deacetylase Inhibition Downregulates Collagen 3A1 in Fibrotic Lung FibroblastsInternational Journal of Molecular SciencesSeptember 27, 2013Xiangyu Zhang, Hui Liu, Thomas Hock, Victor J. Thannickal, Yan Y. Sandersantibody catalog#49-394) was from ProSci Incorporated (Poway, CA, USA); anti-H3Ac (#9671), -H4Ac (#2591), -H4 (#2591) and -β-tubulin (#2128) were from Cell Signaling (Beverly, MA, USA). β-tubulin was used

(17) Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48Science translational medicineAugust 28, 2013Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small SA, Kandel ER.anti-acH3(Lys9), and anti-acH4(Lys12) antibodies were from Cell Signaling Technology (2571, 9671, and 2591, respectively). The MetaMorph software (Molecular Devices) was used for quantification. For DCX (Millipore;

(18) Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathwayBritish Journal of CancerJune 25, 2013P Pandey, P Seshacharyulu, S Das, S Rachagani, M P Ponnusamy, Y Yan, S L Johansson, K Datta, M Fong Lin, S K BatraHorseradish peroxidase-coupled anti-mouse and anti-rabbit IgG secondary antibodies, and enhanced chemiluminescence reagent was 2591 BRITISH JOURNAL OF CANCER purchased from Amersham Biosciences (Buckinghamshire, UK). Transient

(19) Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormonesClinical EpigeneticsDecember 17, 2012Manjeet Kaur Gill-Sharma, Jyoti Choudhuri, Mukhtar Aleem Ansari, Serena D’Souza1808-1 H4K12,11,1:200 (Rb),"1:20,000 (Sigma)",Abcam 1761 ,,1:200 (Rb),"1:4,000 (s.c)",Cell Signalling 2591 H4K Penta,10,1:30 (Rb),"1:20,000 (Sigma)",Millipore 06946 Details of primary and secondary antibodies

(20) Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cellsThe EMBO journalSeptember 12, 2012Cornacchia D, Dileep V, Quivy JP, Foti R, Tili F, Santarella-Mellwig R, Antony C, Almouzni G, Gilbert DM, Buonomo SB.1:500; Anti-H3K27me3 (Abcam, ab6147) 1:1000; Anti-H4K20me3 (Abcam ab9053); Anti-H4K12Ac (Cell Signaling 2591) 1:1000; Anti-Lamin B (Abcam, ab16048) 1:1000; Anti-MeCP2 (Abcam, ab2828) 1:1000; Anti-phosphoHistone

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Acetyl-Histone H4 (Lys12) Antibody

Acetyl-Histone H4 (Lys12) Antibody from Cell Signaling Technology

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Cell Signaling Technology

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Acetyl-Histone H4 (Lys12) Antibody from Cell Signaling Technology

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