Phospho-c-Kit (Tyr719) Antibody 3391L from Cell Signaling Technology

Product Specs
ItemPhospho-c-Kit (Tyr719) Antibody
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number3391L
Quantity300 µl
ApplicationsW
ReactivityH, M
TargetKit (Tyr721) phosphate
ModificationsKit (Tyr721) phosphate
HostRabbit
NCBI Gene AliasesC-Kit, CD117, MASTC, PBT, SCFR
NCBI Full Gene NameKIT proto-oncogene, receptor tyrosine kinase
ClonalityPolyclonal
Research AreaRTK
Molecular Weight120, 145

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) N6-methyl-2′-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesisiScienceJune 16, 2023Yao Li, Zi-Yu Liang, Hai-Lin Wang,Cell Signaling Technology,Cat# 3074; RRID:AB_1147633 Phospho-c-Kit (Tyr719) antibody,Cell Signaling Technology,Cat# 3391; RRID:AB_2131153 Phospho-c-Kit (Tyr568/570) antibody,Cell Signaling Technology,Cat# 48347; RRID:AB_2799336 p44/42

(2) Activity of Anlotinib in the Second-Line Therapy of Metastatic Gastrointestinal Stromal Tumors: A Prospective, Multicenter, In Vitro StudyThe OncologistApril 6, 2023Yongjian Zhou, Chunling Zeng, Xiaofeng Sun, Jun Zhang, Hongyan Qu, Xinhua Zhang, Ye Zhou, Zimin Liu, Xiaojun Wu, Xin Wu, et al.with dimethyl sulfoxide (DMSO). Primary antibodies were p-KITY721 (Cell Signaling Technology (CST), #3391), KIT (Dako, A4502), p-AKTSer473 (CST, #9271), AKT (CST, #9272), p-MAPKThr202/Tyr204 (CST, #9101), MAPK

(3) STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced MyelosuppressionInternational journal of molecular sciencesFebruary 3, 2023Li N, Wang Y, Wang A, Zhang J, Jia C, Yu C, Song Z, Wang S, Liu L, Yi J, et al.(#3462), phospho-FLT3 Tyr591 (#60413), phospho-FLT3 Tyr842 (#4577), cKIT (#3074) and phospho-cKIT Tyr719 (#3391) were obtained from Cell Signaling Technology (Danvers, MA, USA). Specific antibodies against STS1 (#19563),

(4) Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature ReviewInternational Journal of Molecular SciencesJanuary 3, 2023Qichao Ge, Yang Liu, Fan Yang, Guangwei Sun, Jintao Guo, Siyu Sun(cat#9145, CST), c-Kit (cat#3074, CST), Phospho-c-Kit (Tyr703) (cat#3073, CST), Phospho-c-Kit (Tyr719) (cat#3391, CST), Erk1/2 (cat#4695, CST), and Phospho-Erk (Thr202/Tyr204) (cat#4370, CST). Proteins were visualized

(5) Protein Kinase C α and β compensate for each other to promote stem cell factor‐mediated KIT phosphorylation, mast cell viability and proliferationThe FASEB JournalJuly 15, 2022Lakshminarayan Reddy Teegala, Yasmine Elshoweikh, Ravindra Gudneppanavar, Sathwika Thodeti, Sabita Pokhrel, Erik Southard, Charles K. Thodeti, Sailaja Paruchuriinhibitors; Tocris Bioscience, MN). All phospho‐specific primary antibodies (phospho KIT Y719, cat # 3391; total KIT, cat # 3074; phospho p38 T180/Y182, cat # 4511; total p38, cat # 9212; phospho Erk T202/Y204,

(6) G3BP2-KIT drives leukemia amenable to kinase inhibition in Ph-like ALLBlood AdvancesJune 14, 2022Ilaria Iacobucci et al.with the following antibodies from Cell Signaling: KIT (#3074S), phosphorylated KIT (pKIT) Tyr719 (#3391S), pSTAT5 Tyr694 (#9359S), pSTAT3 Tyr705 (#9145S), pPLCγ1 Tyr783 (#14008S), p44/42 MAPK (Erk1/2; #4695S),

(7) Synergistic combination of PMBA and 5-fluorouracil (5-FU) in targeting mutant KRAS in 2D and 3D colorectal cancer cellsHeliyonApril 1, 2022Arem Qayum, Asmita Magotra, Syed Mohmad Shah, Utpal Nandi, P.R. Sharma, Bhahwal Ali Shah, Shashank Kumar Singhbuffer, membranes were incubated overnight at 4 °C with the specific primary antibodies [p-c-Kit (CST #3391), c-Kit (CST #3074)], and subsequently incubated with secondary antibodies [anti-mouse IgG (CST #7076),

(8) Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib‐induced KIT mutations in gastrointestinal stromal tumoursMolecular OncologyApril 1, 2022Juan Liu et al.(Danvers, MA, USA): Phospho‐KIT (Tyr703; D12E12) rabbit mAb (no. 3073), Phospho‐KIT (Tyr719) antibody (no. 3391), Phospho‐anti‐KIT (pY823) rabbit mAb (no. 77522), KIT (Ab81) mouse mAb (no. 3308), Phospho‐AKT (Thr308;

(9) TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosisBritish Journal of CancerJanuary 1, 2022Jianyang Hu et al.passaged for <6 months. Antibodies Anti-KIT (#3074S), anti-HA tag (#3724S), anti-phospho-KIT(T719) (#3391), anti-phospho-ERK (#4370T), anti-phospho-STAT3(T705) (#9145T), anti-phospho-AKT(T473) (#9271) and anti-actin

(10) Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathwayFrontiers in pharmacologyJanuary 1, 2022Zhang S, Fan L, Wang Y, Xu J, Shen Q, Xie J, Zeng Z, Zhou T.Phospho-c-Kit (Tyr568, 1:1,000, #48347, Cell Signaling Technology), Phospho-c-Kit (Tyr719, 1:1,000, #3391, Cell Signaling Technology), c-KIT (1:1,000, 34-8800, Invitrogen), and IL-6 (1:1,000, P620, Invitrogen)

(11) Characterization of receptor tyrosine kinase activation and biological activity of toceranib phosphate in canine urothelial carcinoma cell linesBMC veterinary researchOctober 2, 2021Korec DI, Louke DS, Breitbach JT, Geisler JA, Husbands BD, Fenger JM.1:500 dilution), anti-PDGFRβ antibody (Y92, Cat #32570, Abcam, 1:1000 dilution), p-KIT (Ty719, Cat #3391, Cell Signaling Technology, 1:1000 dilution), and KIT (PC34, Cat #961–976, Calbiochem, 1:500 dilution)

(12) Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal TumorsInternational journal of molecular sciencesSeptember 30, 2021Huang WK, Shi H, Akçakaya P, Zeljic K, Gangaev A, Caramuta S, Yeh CN, Bränström R, Larsson C, Lui WO.diluted in TBS with 0.5% Tween-20, membranes were incubated with primary antibody anti-pTyr719-KIT (#3391, Cell Signalling Technology, Danvers, MA, USA) at 1:1000, anti-KIT (#3308, Cell Signalling Technology,

(13) Oncogenic KIT modulates type I interferon–mediated antitumor immunity in GISTCancer Immunology ResearchMay 1, 2021Mengyuan Liu, Mark S. Etherington, Andrew Hanna, Benjamin D. Medina, Gerardo A. Vitiello, Timothy G. Bowler, Nesteene J. Param, Lillian Levin, Ferdinand Rossi, Ronald P. DeMatteoincubated overnight with primary antibody to phosphorylated Kit (Cell Signaling Technology, antibody# 3391) and then pulled down with Protein A/G agarose beads (Cell Signaling Technology, cat# 9863P). Patient

(14) A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growthJournal of Cancer Research and Clinical OncologyApril 1, 2021Chenguang Bai, Yi Xu, Cen QiuGlostrup, Denmark), 1:1000 phospho-KIT, 1:1000 phospho-MAPK, 1:1000 phospho-AKT (Cell Signaling Technology, 3391, 9102, 9275, Danvers, MA, USA), and 1:3000 glyceraldehyde-3-phosphate dehydrogenase (GAPDH, Abcam, 6C5,

(15) c‐KIT‐ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progressionCancer ScienceFebruary 1, 2021Jian Ma, Xiaohui Liu, Hong Chen, Muhammad Khawar Abbas, Liu Yang, Haimei Sun, Tingyi Sun, Bo Wu, Shu Yang, Deshan ZhouSanta Cruz, USA) and p‐ELK1 (sc‐8406, Santa Cruz), rabbit monoclonal anti‐c‐KIT (#3074, CST), p‐KIT (#3391, CST), ERK1/2 (#9102, CST) and p‐ERK1/2 (#9101, CST). Anti‐β‐actin (sc‐47778, Santa Cruz) was used as

(16) Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatmentJCI InsightJanuary 25, 2021Shuai Ye et al.from Cell Signaling Technology: PDGFRA (3174), phospho-PDGFRA (3170S), c-KIT (3392S), phospho-c-KIT (3391S), phospho-cdc-2 (9111), Cdc-2 (9116S), PARP (9542), Cleaved-PARP (5625S), and Cyclin D1 (2978T). Wee1

(17) The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumorOncogeneDecember 1, 2020Zhang JQ, Bosbach B, Loo JK, Vitiello GA, Zeng S, Seifert AM, Medina BD, Param NJ, Maltbaek JH, Rossi F, et al.and removing cleared lysate. Antibodies were purchased from Cell Signaling Technology (p-KIT, Y719, #3391; KIT, D13A2, #3074; p-AKT, Ser473, #4060; AKT, 11E7, #4685; p-S6, S235/236, #2211; S6, 5G10, #2217;

(18) Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumorsTranslational oncologyNovember 1, 2020Wang Y, Wozniak A, Wellens J, Gebreyohannes YK, Guillén MJ, Avilés PM, Debiec-Rychter M, Sciot R, Schöffski P.phospho-4E-BP1 Ser65, ribosomal protein S6, phospho-S6 Ser240/244 and α-tubulin (catalogue numbers: 3391, 3073, 7292, 7291, 9102, 4370, 9644, 9456, 2217, 5364 and 2144, respectively; all from Cell Signaling Technology

(19) Inhibition of FGF2-Mediated Signaling in GIST-Promising Approach for Overcoming Resistance to ImatinibCancersJune 24, 2020Boichuk S, Galembikova A, Mikheeva E, Bikinieva F, Aukhadieva A, Dunaev P, Khalikov D, Petrov S, Kurtasanov R, Valeeva E, et al.(#4060P), AKT (#4691p), phospho-FGFR Y653/654 (#3476S), FGFR1 (#9740S), FGFR2 (#23328S) phospho-KIT Y719 (#3391S) (Cell Signaling, Danvers, MA, USA), c-KIT (#A4502, Dako, Carpinteria, CA, USA), beta-actin (A00730-200,

(20) Bromodomain and extraterminal domain inhibitor enhances the antitumor effect of imatinib in gastrointestinal stromal tumoursJournal of Cellular and Molecular MedicineFebruary 1, 2020Jianfeng Mu, Pengfei Sun, Zhiming Ma, Pengda Sun(#4108), p‐PI3K (#4228), PI3K (#4255), p‐AKT (#4060), AKT (#9272), p‐mTOR (#2976), mTOR (#2972), p‐cKIT (#3391), cKIT (#3074, Cell Signaling Technology) and β‐actin (#5441, Sigma). 2.10 GIST xenograft models To

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Phospho-c-Kit (Tyr719) Antibody

Phospho-c-Kit (Tyr719) Antibody from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-c-Kit (Tyr719) Antibody from Cell Signaling Technology

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