Anti-Factor VIII Antibody GMA-8023 from Green Mountain Antibodies

Product Specs
ItemAnti-Factor VIII Antibody
CompanyGreen Mountain Antibodies
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberGMA-8023
Quantity0.1 mg
ApplicationsELISA, bio-layer interferometry, BL
Conjugate/TagUnconjugated
FormatLyophilized from a ≥1 mg/ml solution in 20 mM NaH2PO4 0.15 M NaCl, 1.0% (w/v) mannitol, pH 7.4
Reactivityhuman
TargetFactor VIII, Factor VIII A2 domain
IsotypeIgG2a
Clone2G10
Hostmouse
ImmunogenFactor VIII
NCBI Full Gene Namecoagulation factor VIII
NCBI Gene AliasesAHF, DXS1253E, F8B, F8C, FVIII, HEMA
ClonalityMonoclonal

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Green Mountain Antibodies

PO Box 1283

One Mill St, Burlington, VT 05402

United States

Phone: 802.865.6230
Fax: 802.865.0115

Email: Productsales@greenmoab.com

Company Profile

Website: https://greenmoab.com/

(1) Selective human factor VIII activity measurement after analytical inâ€line purificationResearch and Practice in Thrombosis and HaemostasisOctober 13, 2022Andrea Engelmaier, Gerald Schrenk, Manfred Billwein, Herbert Gritsch, Christoph Zlabinger, Alfred WeberMATERIALS AND METHODS 2.1 Materials The following monoclonal anti‐FVIII antibodies were used: GMA‐8024, GMA‐8023, and GMA‐012, all from Green Mountain Antibodies, ESH‐4, ESH‐8, and N55195 (American Diagnostica), and

(2) Young mice administered adult doses of AAV5-hFVIII-SQ achieve therapeutic factor VIII expression into adulthoodMolecular Therapy - Methods & Clinical DevelopmentSeptember 8, 2022Lening Zhang, Bridget Yates, Ryan Murphy, Su Liu, Lin Xie, Britta Handyside, Choong-Ryoul Sihn, Taren Bouwman, Nicole Galicia, Danielle Tan, et al.protein in sodium citrate-anticoagulated plasma. The assay used human-specific anti-FVIII capture (GMA-8023, Green Mountain Antibodies) and detection (F8C-EIA, Affinity Biologics) antibody pairs to specifically

(3) Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primatesNature communicationsMay 4, 2022Milani M, Canepari C, Liu T, Biffi M, Russo F, Plati T, Curto R, Patarroyo-White S, Drager D, Visigalli I, et al.hFVIII antigen. Microtiter plates were coated with anti-hFVIII binding Ab (Green Mountain Antibodies #GMA8023, 0.2 µg/well in 0.05 M carbonate buffer, Sigma) over night at 4 °C and then blocked 1 h at room temperature

(4) Preclinical assessment of an optimized AAV-FVIII vector in mice and non-human primates for the treatment of hemophilia AMolecular Therapy - Methods & Clinical DevelopmentMarch 10, 2022Liron Elkouby et al.B-domain deleted hFVIII (Xyntha Solofuse) for a standard curve. A biotinylated anti-hFVIII antibody (GMA-8023, Green Mountain Antibodies; diluted to 1 μg/mL) was added to the plates to bind to the captured hFVIII

(5) Activity of transgene-produced B-domain–deleted factor VIII in human plasma following AAV5 gene therapyBloodNovember 26, 2020Steffen Rosen et al.diluted 1:50 in sample diluent and added to the plate. After incubation, biotinylated detection antibody (GMA-8023; Green Mountain Antibodies) was added, followed by streptavidin-horseradish peroxidase, 3,39, 5,59-tetramethylbenzidine

(6) Hemophilia A ameliorated in mice by CRISPR-based in vivo genome editing of human Factor VIIIScientific ReportsDecember 1, 2019Hainan Chen et al.temperature (RT). After washing the plates, a secondary biotinylated anti-human mouse FVIII antibody (GMA-8023, Green Mountain Antibodies) was added and plates incubated for another hour. After several washing steps,

(7) Prednisolone Does Not Regulate Factor VIII Expression in Mice Receiving AAV5-hFVIII-SQ: Valoctocogene RoxaparvovecMolecular Therapy. Methods & Clinical DevelopmentNovember 21, 2019Lening Zhang, Britta Handyside, Ryan Murphy, Choong-Ryoul Sihn, Lin Xie, Catherine Vitelli, Danielle Harmon, Sílvia Sisó, Su Liu, Sherry Bullens, Stuart Bunting, Sylvia Fongassessed using a chromogenic FXa-activating assay. The ELISA utilized human-specific anti-FVIII capture (GMA-8023, Green Mountain Antibodies, Burlington, VT, USA) and detection (F8C-EIA, Affinity Biologicals, Ancaster,

(8) Gene Therapy with BMN 270 Results in Therapeutic Levels of FVIII in Mice and Primates and Normalization of Bleeding in Hemophilic MiceMolecular therapy : the journal of the American Society of Gene TherapyFebruary 7, 2018Bunting S, Zhang L, Xie L, Bullens S, Mahimkar R, Fong S, Sandza K, Harmon D, Yates B, Handyside B, et al.electrochemiluminescent assay (ECLA). Both assays used the same human-specific anti-FVIII capture (GMA-8023; Green Mountain Antibodies) and detection (Affinity Biologics) antibody pairs to specifically measure

(9) AAV5–Factor VIII Gene Transfer in Severe Hemophilia ANew England Journal of MedicineDecember 28, 2017Savita Rangarajan et al.recombinant FVIII replacement therapy. Human FVIII was immunoprecipitated (Capture Ab for heavy chain: GMA8023, Green Mountain Antibodies; capture antibody for light chain: GMA8001, Green Mountain Antibodies) from

(10) The diversity of the immune response to the A2 domain of human factor VIIIBloodApril 4, 2013Rebecca C. Markovitz, John F. Healey, Ernest T. Parker, Shannon L. Meeks, Pete Lollar

(11) Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinityBiochemistryAugust 28, 2001H Wakabayashi, M E Koszelak, M Mastri, P J Fay

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Anti-Factor VIII Antibody from Green Mountain Antibodies

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Anti-Factor VIII Antibody from Green Mountain Antibodies

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