InVivoMAb anti-mouse TIM-1 (CD365) BE0289-R100mg from Bio X Cell

Description

Bio X Cell InVivoMAb anti-mouse TIM-1 (CD365) Monoclonal Antibody has the following reported applications: in vivo TIM-1 activation, in vitro T cell stimulation/activation, Functional assays, ELISA, Flow cytometry. It features greater than 95% purity, ultra-low endotoxin levels, and are preservative, stabilizer, and carrier protein-free

Product Specs
ItemInVivoMAb anti-mouse TIM-1 (CD365)
CompanyBio X Cell
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberBE0289-R100mg
Quantity100 mg
Applicationsin vivo TIM-1 activation, in vitro T cell stimulation/activation, Functional assays, ELISA, Flow cytometry
ConcentrationLot specific,typically between 4-11 mg/ml
Conjugate/TagUnconjugated
ReactivityMouse
TargetTIM-1
IsotypeIgG2a, κ
Clone3B3
Hostrat
NCBI Full Gene Namehepatitis A virus cellular receptor 1
NCBI Gene AliasesKIM-1, TIM-1, Tim1, Timd1
ClonalityMonoclonal
ImmunogenMouse TIM-1 (signal and IgV domains) mouse IgG2a Fc fusion protein
Antibody TypePrimary Antibody
Purity>95%, Determined by SDS-PAGE
FormatPBS, pH 7.0, Contains no stabilizers or preservatives
Research AreaApoptosis, Cancer Biology, Immune Checkpoint Protein, Immunology

Specifications/Features

Other available quantities: Available in 1, 5, 10, 25, 50, 100 mg and bulk sizes. Academic discount available.

Endotoxin: <2EU/mg (<0.002EU/µg), Determined by LAL gel clotting assay

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Bio X Cell

39 Labombard Rd

Lebanon, NH 03766

United States

Phone: 1-866-787-3444

Email: customerservice@bxcell.com

Company Profile

Website: bioxcell.com

(1) Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivityJournal of immunology (Baltimore, Md. : 1950)November 1, 2010Lee HH, Meyer EH, Goya S, Pichavant M, Kim HY, Bu X, Umetsu SE, Jones JC, Savage PB, Iwakura Y, et al.

(2) Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferationJournal of immunology (Baltimore, Md. : 1950)February 1, 2009Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TB.

(3) Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in miceThe Journal of clinical investigationFebruary 1, 2008Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, et al.

(4) Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector functionThe Journal of experimental medicineJuly 9, 2007Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, et al.

(5) TIM-1 induces T cell activation and inhibits the development of peripheral toleranceNature immunologyMay 1, 2005Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, Berry GJ, Nagumo H, Freeman GJ, Umetsu DT, et al.

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