Fig 1: H2d-Dependent Protection against MCMV Lacking m157 Requires Cytotoxic NK Cells(A–F) Splenic viral titers in mice depleted of total NK cells or CD8+T cells or where Ly49H+ receptors on NK cells were blocked. Data represent a composite of two independent experiments with three to seven mice per group, with individual points representing a single mouse using (A) H2b-expressing B10 mice, (B) B10 and H2d-expressing B10.D2 mice, (C) H2Dd-expressing (D8-KODO) mice, and (D–F) D8-KODO mice with wild-type, heterozygous, or no expression of (D) perforin (Prf1), (E) granzyme B (Gzmb), and (F) NKG2D (Klrk1).
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