Fig 1: (A): Western blot analysis of phosphorylated extracellular signal-regulated kinase 1 and 2 (p-ERK1/2) protein expression relative to ß-actin. (B): Effect of ?-Radiation Exposure and/or Zinc Oxide–Caffeic Acid Nanoparticles treatment on the phosphorylated extracellular signal-regulated kinase 1 and 2 (p-ERK 1/2) protein expression relative to ß-actin in the thigh muscle (control) or tumor tissues.Results are mean ± SE of 3 mice. Values with dissimilar superscripts are significantly different. C: control, E: Solid Ehrlich (EC) bearing mice, R: mice exposed to 2 Gy of whole-body gamma (?)-irradiation/week for 3 consecutive weeks, and ZnO-CA: Mice injected intraperitoneally with 5 mg of Zinc Oxide–Caffeic acid nanoparticles (ZnO-CA NPs)/100 g bodyweight, every other day for 3 consecutive weeks. Relative gene expression was measured in thigh muscle of non EC bearing mice (C and ZnO-CA groups) or tumor tissues of solid EC bearing mice of different treated groups. P-value < 0.001.