Fig 2: Inactivation of C/EBPß/AEP pathway rescues dopaminergic neurons in a-SNCA transgenic mice.a Western blot showing C/EBPß, AEP, NQO1, TH, MAO-B, and a-Syn expressing and processing in the brain of a-SNCA transgenic, deletion of AEP and C/EBPß± from a-SNCA transgenic mice. Quantification of western blotting (n = 4 per group, *P < 0.05 vs 14 months old a-SNCA transgenic mouse, one-way ANOVA). b Immunohistochemistry and the quantification of C/EBPß and delta-secretase in the striatum and SN (n = 5–6 per group, *P < 0.05 vs 14 months old a-SNCA transgenic mouse, one-way ANOVA). Scale bar, 50 µm. c Immunofluorescent staining and the quantification of TH and AEP in SN (mean ± s.e.m.; n = 5–6 per group, *P < 0.05 vs 14 months old a-SNCA transgenic mouse, one-way ANOVA). Scale bar, 20 µm. d AEP and MAO-B activity assay in the SN samples (mean ± s.e.m.; n = 3 per group, *P < 0.05 vs 14 months old a-SNCA transgenic mouse, one-way ANOVA).