Fig 1: (a) DNMT3a labelling (arrowheads). The enzyme localized in the heterochromatic regions and at its surface. Bars: 1 µm (control); 500 nm (KBrO3 and recovery). (b) TET2 labelling (arrowheads). Note the localization at euchromatin-heterochromatin surface. Bars: 500 nm (control and KBrO3); 1 µm (recovery). (c) Western blot analysis of potassium bromate-treated cells with antibody targeting DNMT3a and TET2 (see Figure S1). (d,e) Histograms representing the abundancy of DNMT3a and TET2 per nucleus. Asterisks identify colloidal gold counting-revealed significant differences. Mean with SEM are reported (*: p Value < 0.05; ***: p Value < 0.001).