Fig 2: Correlation between immune cell infiltration and PSRC1 in LUAD. (A) Correlation between PSRC1 expression level in LUAD and infiltration of 24 immune cells. Relationship between PSRC1 expression and infiltration of (B) mast cells, (C) eosinophils, (D) dendritic cells (DC), (E) immature dendritic cells (iDC), (F) type 2 T-helper (Th2) cells and (G) γδ T (Tgd) cells.

Fig 3: Differentially expressed genes in LUAD patients with high and low PSRC1 expression. (A) Volcano map of differentially expressed genes based on PSRC1 expression. (B) Heat maps of the first five up-regulated and the first five down-regulated genes were selected according to the expression status of PSRC1. (Pearson). (C) GO/KEGG enrichment analysis of PSRC1 expression-related genes. *p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviations: PSRC1, Proline and serine rich coiled-coil 1; LUAD, lung adenocarcinoma; GO, Gene Ontology.

Fig 4: Kaplan-Meier curve for OS in LUAD. (A) Overall survival and (B) progress free interval. Kaplan-Meier survival curves of 90 LUAD patients with high and low PSRC1-expressing tumors (C) Overall survival and (D) progression free interval.

Fig 5: Correlation between PSRC1 expression and clinicopathologic features in patients with LUAD in TCGA database (p < 0.05). The correlation between PSRC1 expression and pathologic T stage (A), pathologic stage (B), primary therapy outcome (C), age (D), gender (E) and number pack year smoked (F) of patients with LUAD. Abbreviations: PSRC1, Proline and serine rich coiled-coil 1; LUAD, lung adenocarcinoma; TCGA, The Cancer Genome Atlas.