Fig 1: Relative expression fold change of glycolysis-associated genes detected by RT-qPCR in WWOX-silencing 1BR.3.N cells after 48 h incubation in four tested condition. Bar graphs showing the relative mRNA expression (the ratio of the target gene relative to the reference genes RPS17, RPLP0, H3F3A) of WWOX (a), HIF1A (b), the WWOX/HIF1A ratio (c) and all WWOX/HIF-related genes including those involved in glucose transport (SLC2A1 (d), SLC2A4 (e)), glycolytic pathway (HK2 (f), ENO1 (g), PFK (h), PKM2 (i), LDHA (j)), PDK (k), PDHA (l), CS (m) and ACLY (n). Results of ANOVA with a post-hoc Tukey-Test are shown as mean ± SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001.