Fig 2: NEUROG3+ cells have unique gene expression signatures. (A) Heatmap demonstrates the average expression of the 10 most upregulated and two most downregulated transcripts in NEUROG3+ cells compared to other pancreatic epithelial cell types. The color scale is based on the normalized Z-score of each transcript. (B) Violin plots display the expression levels of PROX1 and GHRL in different cell populations. Each dot represents one cell.

Fig 3: The GHRL expression in different stages of GC Correa’ cascade. CNAG, chronic non-atrophic gastritis; LGIN, low-grade intraepithelial neoplasia; HGIN, high-grade intraepithelial neoplasia; EGC, early GC; CAG, chronic atrophic gastritis; IM, intestinal metaplasia; NC, normal control.

Fig 4: (A) Difference in GHRL expression in pan-carcinoma (GEPIA), low expression in STAD at RNA level (B). Red mark represents that GHRL expression in tumor is higher than adjacent issue; green mark represents that GHRL expression in tumor is lower than that in adjacent issue. *p < 0.05.

Fig 5: Correlation between the expression of GHRL and chemokines in GC. (A) Correlation between GHRL expression and chemokines in GC available at TISIDB database. (B) Correlation between GHRL expression and chemokine receptors in GC available at TISIDB database.