Fig 1: Ido2-deficient mice exhibit increased liver regeneration. WT mice and Ido2-KO mice were subjected to 70% PHx and were sacrificed and analyzed at the indicated time points (n=5-7 each). (A) Liver body ratio of WT and Ido2-KO mice were measured following PHx. (B) Expression of pro-proliferative genes in the liver was measured at indicated time points after PHx. The results were normalized to the expression of 18S rRNA. (C) Immunohistochemical staining for PCNA expression in liver sections from experimental mice after PHx. The frequency of PCNA+ cells was counted in 10 high-power fields from each liver tissue (scale bar, 200 µm. *P<0.05; #P<0.05 vs. 0 h in each mouse. WT, wild-type; Ido2, indoleamine 2,3-dioxygenase 2; KO, knockout; PHx, partial hepatectomy.