Fig 2: Gene set enrichment analysis (GSEA). a Cell cycle pathway. B Erbb signaling pathway. c Gnrh signaling pathway. d Insulin signaling pathway. e mTOR signaling pathway. f P53 signaling pathway. g TGF Beta signaling pathway. h seven PTTG1-related signaling pathways.

Fig 3: Relationships between PTTG1 and PPI, MSI, TMB, Neoantigen in KIRC. a Protein–protein interaction (PPI) network. B Correlations between PTTG1 and MSI. c Correlations between PTTG1 and neoantigen. d Correlations between PTTG1 and TMB.

Fig 4: Immunohistochemistry staining of KIRC tissues. a-h The results of immunohistochemistry staining indicated that PTTG1 was highly expressed in KIRC tissues.

Fig 5: Relationships between PTTG1 and an immune checkpoint molecules; b immune cells pathway; c tumor immune infiltration; and d tumor microenvironment in KIRC.