Anti-KCNK1 (TWIK-1) (extracellular) Antibody APC-110 from Alomone Labs, Ltd.

Description

Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the human K2P1.1 channel. Anti-KCNK1 (TWIK-1) (extracellular) Antibody (#APC-110) can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting KCNK1 in living cells. It has been designed to recognize KCNK1 from mouse, rat and human samples

Product Specs
ItemAnti-KCNK1 (TWIK-1) (extracellular) Antibody
CompanyAlomone Labs, Ltd.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAPC-110
Brand/TrademarkAlomone Labs Ltd
Quantity1 X 50 mcl, 1 X 0.2 ml, 1 X 25 mcl
ReactivityHuman (Tested);Mouse (Tested);Rat (Tested)
FormatReconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3., Lyophilized Powder
ClonalityPolyclonal
ApplicationsIF, IHC, WB
Conjugate/TagUnconjugated
HostRabbit
Domain/Region/Terminusextracellular
Antibody TypePrimary
NCBI Gene AliasesDPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1
Concentration08 mg/ml
PurityAffinity purified on immobilized antigen
IsotypeIgG
ImmunogenSynthetic peptide
Gene NameKCNK1
TargetKCNK1 Channel
ValidationAs per applications, See images, contact for clarifications
NCBI Full Gene Namepotassium two pore domain channel subfamily K member 1
pH RangepH 7.4

Specifications/Features

starting price for North American orders, for exact pricing view product page

Sequence

RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human KCNK1

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Alomone Labs, Ltd.

PO Box 4287

Jerusalem 91042

Israel

Phone: +972-2-587-2202
+972-2-587-1101

Company Profile

Website: http://www.alomone.com/

(1) TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 ExpressionCellsOctober 14, 2021Kwon O, Yang H, Kim SC, Kim J, Sim J, Lee J, Hwang EM, Shim S, Park JY.

(2) Pressure-dependent modulation of inward-rectifying K⁺ channels: implications for cation homeostasis and K⁺ dynamics in glaucomaAmerican journal of physiology. Cell physiologyAugust 1, 2019Fischer RA, Roux AL, Wareham LK, Sappington RM.

(3) Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cellsPloS oneJanuary 1, 2018Thompson K, Chen J, Luo Q, Xiao Y, Cummins TR, Bhatwadekar AD.

(4) Role of dorsal root ganglion K2p1.1 in peripheral nerve injury-induced neuropathic painMolecular painJanuary 1, 2017Mao Q, Yuan J, Ming X, Wu S, Chen L, Bekker A, Yang T, Tao YX.

(5) mGluR3 Activation Recruits Cytoplasmic TWIK-1 Channels to Membrane that Enhances Ammonium Uptake in Hippocampal AstrocytesMolecular neurobiologyNovember 1, 2016Wang W, Kiyoshi CM, Du Y, Ma B, Alford CC, Chen H, Zhou M.

(6) A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytesNature communicationsJanuary 1, 2014Hwang EM, Kim E, Yarishkin O, Woo DH, Han KS, Park N, Bae Y, Woo J, Kim D, Park M, et al.3F10, 1:1,000), anti-FLAG antibody (Sigma; F1804, 1:1,000) or anti-TWIK-1 antibody (Alomone Labs; # APC-110, 1:500). Blots were then washed and incubated with horseradish peroxidase-conjugated goat antimouse,

(7) The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartmentsFrontiers in cellular neuroscienceJanuary 1, 2013Wang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M.

(8) Impact of global cerebral ischemia on K+ channel expression and membrane properties of glial cells in the rat hippocampusNeurochemistry internationalDecember 1, 2010Pivonkova H, Benesova J, Butenko O, Chvatal A, Anderova M.

(9) TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slicesThe Journal of neuroscience : the official journal of the Society for NeuroscienceJuly 1, 2009Zhou M, Xu G, Xie M, Zhang X, Schools GP, Ma L, Kimelberg HK, Chen H.

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