Anti-KAT13D / CLOCK antibody ab3517 from Abcam

Product Specs
ItemAnti-KAT13D / CLOCK antibody
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab3517
Antibody TypePrimary
ClonalityPolyclonal
ApplicationsImmunocytochemistry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
IsotypeIgG
Quantity200 UL
HostRabbit
Conjugate/TagUnconjugated
Concentration1 mg/ml
Gene NameCLOCK
ReactivityHuman, Mouse
TargetKAT13D / CLOCK

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Abcam

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Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCKFrontiers in Cell and Developmental BiologyNovember 7, 2023Bo Xie, Hongyan Yuan, Xuqiang Zou, Mingjie Lu, Yixin Zhang, Dan Xu, Xuelian Peng, Di Wang, Manzhu Zhao, Xiujie Wenantibodies against p75NTR (1:100, ab52987, Abcam), BMAL1 (1:100, DF10308, Affinity), or CLOCK (1:100, ab3517, Abcam) at 4 °C overnight. The following day, the cells were washed and incubated with goat anti-rabbit

(2) A druggable copper-signalling pathway that drives inflammationNatureMay 1, 2023Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, et al.Ms), CLOCK (Proteintech, 18094-1-AP, WB 1:1,000, Hu, KD/KO validated by manufacturer), CLOCK (Abcam, ab3517, WB 1:1,000, Ms), CTR1 (Abcam, ab129067, clone EPR7936, lot GR3414582-4 and GR81444-2, WB 1:1,000, Hu,

(3) BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosisMolecular Therapy - Nucleic AcidsMarch 14, 2023Li Jinteng, Xu Peitao, Yu Wenhui, Ye Guiwen, Ye Feng, Xu Xiaojun, Su Zepeng, Lin Jiajie, Che Yunshu, Zhang Zhaoqiang, et al.Cell Signaling Technology), anti-TTK antibody (catalog no. ab11108; Abcam), anti-CLOCK antibody (catalog no. ab3517; Abcam), anti-OCN antibody (catalog no. 29560; Sab), anti-GAPDH (catalog no. 5174S; Cell Signaling Technology),

(4) Identification of Novel Targets for Treatment of Dilated Cardiomyopathy Based on the Ferroptosis and Immune HeterogeneityJournal of inflammation researchJanuary 1, 2023Lu H, Xie Y, Zhou Z, Hong P, Chen J.(bs-17563R, 1:200, Bioss, China), CD19 (14–0194-82, 1:100, ThermoFisher, USA), 4-hydroxynonenal (4-HNE) (ab3517, Abcam, Cambridge, UK). The secondary antibodies used are as follows: Goat Anti-Mouse IgG H&L (TRITC)

(5) Co-alterations of circadian clock gene transcripts in human placenta in preeclampsiaScientific reportsOctober 25, 2022Zhou G, Winn E, Nguyen D, Kasten EP, Petroff MG, Hoffmann HM.blocked in 3% milk for 1 h at RT and incubated with rabbit anti-human CLOCK primary antibody (1:1000, ab3517, Abcam, Cambridge, UK, RRID: AB_303886) for 16 h at 4 °C. After washing, the blot was incubated in goat anti-rabbit IgG-HRP

(6) Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer''s disease neuropathologyBrain pathology (Zurich, Switzerland)May 1, 2022Niu L, Zhang F, Xu X, Yang Y, Li S, Liu H, Le W.Cambridge, UK), anti‐Cryptochrome I/CRY1 (ab104736, 1:200, Abcam, Cambridge, UK), anti‐KAT13D/CLOCK (ab3517,1:500, Abcam, Cambridge, UK), phospho‐Tau (Thr231) monoclonal antibody (AT180) (MN1040, 1:100, Thermo Fisher Scientific

(7) miR-92b-3p Exerts Neuroprotective Effects on Ischemia/Reperfusion-Induced Cerebral Injury via Targeting NOX4 in a Rat ModelOxidative Medicine and Cellular LongevityMarch 30, 2022Yongpan Huang, Jiayu Tang, Xiaojuan Li, Xian Long, Yansong Huang, Xi ZhangMA, USA), sealed with 5% skim milk powder, and incubated with the anti-NOX4 primary antibody (cat. ab3517: Abcam, Cambridge, UK) overnight. Then, the protein was incubated again with the HRP-coupled secondary

(8) Proteome-wide profiling of transcriptional machinery on accessible chromatin with biotinylated transposonsScience advancesOctober 22, 2021Zhang H, Qin Z, Yue X, Liu Y, Sun X, Feng J, Xu Z, Zhao J, Li K, Qiu J, et al.Kit,Beyotime,P0101 ,, Immunostaining antibodies,Immunostaining antibodies,Immunostaining antibodies CLOCK,Abcam,ab3517 H3K27AC,SAB,#39193 CoraLite488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L),Proteintech,SA00013-2 ,, ChIP-seq

(9) Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle DegenerationInternational journal of molecular sciencesSeptember 30, 2021Cha S, Lee SM, Wang J, Zhao Q, Bai D.instruction. The following antibodies were used: Bmal1 (1:250, #NB100-2288, Novusbio), Clock (1:100, #ab3517, Abcam), GFP (1:100, #NB600-597, Novusbio), Acan (1:200, #13880-1-AP, Proteintech), Collagen II (1:100,

(10) L-3,4-Dihydroxyphenylalanine Recovers Circadian Rhythm Disturbances in the Rat Models of Parkinson's Disease by Regulating the D1R-ERK1/2-mTOR PathwayFrontiers in Aging NeuroscienceAugust 19, 2021Shuyuan Yang, Ying Wan, Na Wu, Lu Song, Zhihua Liu, Jiahao Zhao, Ying Liu, Zhenguo Liu, Jing Gantyrosine hydroxylase (TH; 1:1,000, ab41528, Abcam, UK), BMAL1 (1:1,000, ab3350, Abcam), CLOCK (1:1,000, ab3517, Abcam), ERK1/2 (1:1,000, 4695S, Cell Signaling, USA), p-ERK (1:1,000, 4370S, Cell Signaling, USA),

(11) Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsyMolecular brainJuly 14, 2021Wu H, Liu Y, Liu L, Meng Q, Du C, Li K, Dong S, Zhang Y, Li H, Zhang H.were used: anti-Bmal1 (Abcam, ab93806), anti-β-actin (Proteintech, 66009-1-Ig), anti-CLOCK (Abcam, ab3517), anti-Per2 (Abcam, ab179813), anti-Cry1 (Proteintech, 13474-1-AP), anti-NeuN (Merck Millipore, ABN90),

(12) NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseasesRedox biologyMay 1, 2021Park MW, Cha HW, Kim J, Kim JH, Yang H, Yoon S, Boonpraman N, Yi SS, Yoo ID, Moon JS.(PS1). 2.3 Reagents and antibodies The following antibodies were used: polyclonal rabbit anti-NOX4 (ab3517, Abcam, Cambridge, UK), polyclonal rabbit anti-4-HNE antibody (ab3517, Abcam, Cambridge, UK), polyclonal

(13) Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cellseLifeApril 23, 2021Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S.gels, transferred to polyvinylidene difluoride membranes, and probed with antibodies against Clock (ab3517; Abcam, Cambridge, UK), E-cadherin (AF748; R and D systems, Minneapolis, MN), Claudin1 (13050–1-AP;

(14) Epigallocatechin‑3‑gallate inhibits self‑renewal ability of lung cancer stem‑like cells through inhibition of CLOCKInternational journal of molecular medicineDecember 1, 2020Jiang P, Xu C, Zhang P, Ren J, Mageed F, Wu X, Chen L, Zeb F, Feng Q, Li S.for 1 h at room temperature. The following primary antibodies were used: Anti-CLOCK (1:1,000; cat no. ab3517, Abcam), anti-CD133 (1:1,000; cat no. ab216323, Abcam), anti-CD44 (1:1,000; cat no. ab189524, Abcam),

(15) Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer's DiseaseInternational journal of molecular sciencesOctober 23, 2020Yoo ID, Park MW, Cha HW, Yoon S, Boonpraman N, Yi SS, Moon JS.USA). 4.2. Reagents and Antibodies The following antibodies were used: polyclonal rabbit anti-CLOCK (ab3517, Abcam, (Cambridge, UK)), polyclonal rabbit anti-BMAL1 antibody (NB100-2288, Novus Biologicals), monoclonal

(16) Chronic Timed Sleep Restriction Attenuates LepRb-Mediated Signaling Pathways and Circadian Clock Gene Expression in the Rat HypothalamusFrontiers in NeuroscienceSeptember 8, 2020Qi Sun, Yang Liu, Wei Wei, Dan Wu, Ren Lin, Deliang Wen, Lihong Jiaprocured from Cell Signaling Technology (MA, United States). The primary antibodies against CLOCK (#ab3517) and phosphorylated-PI3K (p-PI3K, Y607, #ab182651) were purchased from Abcam (Cambridge, MA, United

(17) Circadian Clock Regulation of Developmental Time in the KidneyCell reportsMay 19, 2020Dan H, Ruan T, Sampogna RV.AF1556; RRID:AB_354858 Aquaporin-2,Sigma-Aldrich,Cat# A7310; RRID:AB_476762 Clock for ChIP,Abcam,Cat# AB3517; RRID:AB_303866 Bmal1 Rabbit,Novus,Cat# NB100–2288; RRID:AB_10000794 Alexa Fluor 488 rat secondary

(18) Noninvasive 40-Hz Light Flicker Rescues Circadian Behavior and Abnormal Lipid Metabolism Induced by Acute Ethanol Exposure via Improving SIRT1 and the Circadian Clock in the Liver-Brain AxisFrontiers in PharmacologyMarch 25, 2020Youli Yao, Wenjiang Zhang, Ruibo Ming, Qiyu Deng, Along Zuo, Shengli Zhang, Ying Ying, Yingying Zhao, Junxian Marecorded for 5 days. Antibodies and Reagents Anti-SREBP1 (ab28481), anti-GAPDH (ab8245), anti-CLOCK (ab3517), anti-BMAL1 (ab228594), and anti-SIRT1 (ab110304) were purchased from Abcam (Cambridge, MA, USA). Antibodies

(19) Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor MicroenvironmentCancer discoveryMarch 1, 2020Chen P, Hsu WH, Chang A, Tan Z, Lan Z, Zhou A, Spring DJ, Lang FF, Wang YA, DePinho RA.and 30 sec off). Solubilized chromatin was then incubated with a mixture of antibody [CLOCK (Abcam, #ab3517) or BAML1 (CST, #14020S)] and Dynabeads (Life Technologies) overnight. Immune complexes were then washed

(20) Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylationNature communicationsDecember 18, 2019Hasegawa S, Fukushima H, Hosoda H, Serita T, Ishikawa R, Rokukawa T, Kawahara-Miki R, Zhang Y, Ohta M, Okada S, et al.Slurry (Merck Millipore) and then immunoprecipitated for 48 h at 4 °C using 5 μg of anti-CLOCK antibody (ab3517, Abcam, Cambridge, UK) or anti-rabbit IgG (ab46540, Abcam). Chromatin–antibody complexes were collected

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12/14/2015Anti-Clock Antibody A RWe have used clock antibody to measure levels of clock protein in the human fibroblast cells at different time point.

Anti-KAT13D / CLOCK antibody from Abcam

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Anti-KAT13D / CLOCK antibody from Abcam

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