Anti-Heparan Sulfate Proteoglycan 2/Perlecan antibody [A7L6] ab2501 from Abcam

Product Specs
ItemAnti-Heparan Sulfate Proteoglycan 2/Perlecan antibody [A7L6]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab2501
Antibody TypePrimary
ApplicationsImmunohistochemistry (Frozen sections)
Quantity50 UG
CloneA7L6
ClonalityMonoclonal
HostRat
IsotypeIgG2a
Conjugate/TagUnconjugated
Concentration1 mg/ml
Gene NamehspG2
ReactivityHuman
TargetHeparan Sulfate Proteoglycan 2

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Abcam

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Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan PerlecanInternational journal of molecular sciencesAugust 28, 2023Provenzale I, De Simone I, Gibbins JM, Heemskerk JWM, van der Meijden PEJ, Jones CI.R&D systems (Abingdon, UK). The antibody against human heparan sulfate proteoglycan 2 and perlecan (Ab2501) was obtained from Abcam (Cambridge, UK). Secondary antibodies AF488-labeled anti-rat IgG and AF647-Germanylabeled

(2) IFNγ binding to extracellular matrix prevents fatal systemic toxicityNature immunologyMarch 1, 2023Kemna J, Gout E, Daniau L, Lao J, Weißert K, Ammann S, Kühn R, Richter M, Molenda C, Sporbert A, et al.control/PE/MOPC-173/BD 558595/mouse IgG2a, κ). For histology, the following regents were used: (HSPG 2/A7L6/Abcam ab2501/rat IgG2a), (goat anti-rat/Alexa 568/Invitrogen A11077), (CD146/Alexa 647/ME-9F1/Biolegend 134702/rat

(3) Protectin DX Relieve Hyperoxia-induced Lung Injury by Protecting Pulmonary Endothelial GlycocalyxJournal of inflammation researchJanuary 1, 2023Liang Z, Yue H, Xu C, Wang Q, Jin S.paraformaldehyde, blocked with donkey serum (Solarbio, Beijing), and incubated with anti-HSPG2 (Abcam, cat. no. ab2501) and anti-vWF (von Willebrand factor, Sigma‐Aldrich, cat. no. AB7356). After incubating with a second

(4) Peripheral Nerve Decellularization for In Vitro Extracellular Matrix Hydrogel Use: A Comparative StudyACS Biomaterials Science & EngineeringJune 13, 2022Emory Gregory, In Ha Baek, Nikolas Ala-Kokko, Reagan Dugan, Luis Pinzon-Herrera, Jorge Almodóvar, Young Hye Songab6586), mouse anti-chondroitin sulfate (CSPG; 1:400; ab11570), rabbit anti-heparan sulfate (HSPG; 1:400; ab2501), rabbit anti-glial fibrillary acidic protein (GFAP; 1:100; ab16997), and rabbit anti-Ki67 (1:200; ab16667). 2.2.

(5) Longitudinal Imaging of the Skull Base Synchondroses Demonstrate Prevention of a Premature Ossification After Recifercept Treatment in Mouse Model of AchondroplasiaJBMR PlusFebruary 1, 2022Guylene Rignol et al.over night at 4°C with anti‐collagen X (Abcam, ab58632), anti‐heparan sulfate proteoglycan (Abcam, ab2501) or anti‐bone alkaline phosphatase (R&D, AF2909) primary antibodies and 1 hour at room temperature with

(6) Intramuscular Exposure to a Lethal Dose of Ricin Toxin Leads to Endothelial Glycocalyx Shedding and Microvascular Flow Abnormality in Mice and SwineInternational journal of molecular sciencesNovember 16, 2021Sapoznikov A, Gal Y, Evgy Y, Aftalion M, Katalan S, Sabo T, Kronman C, Falach R.polyclonal anti-HA (ab53842), rabbit monoclonal anti-syndecan-1 (ab128936), rat monoclonal anti-HS (ab2501) and rabbit polyclonal anti-VE-cadherin (ab33168) (Abcam, Cambridge, MA, USA). Alexa Fluor 594-coupled

(7) Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects against cartilage degenerative mitochondrial dysfunction in rats chondrocytesChinese Medical JournalJanuary 20, 2021Rui Wang, Talatibaike Maimaitijuma, Yuan-Yuan Ma, Yang Jiao, Yong-Ping Caoand incubated with the primary antibodies, collagen II (ab34712, Abcam, Cambridge, UK), proteoglycan (ab2501, Abcam), and glyceraldehyde-3-phosphate dehydrogenase (ab128915, Abcam), overnight at 4°C. Then, rabbit

(8) 3D distribution of perlecan within intervertebral disc chondrons suggests novel regulatory roles for this multifunctional modular heparan sulphate proteoglycanEuropean Cells and MaterialsJanuary 17, 2021AJ Hayes, Raymond Purves Bone and Joint Laboratories, Level 10, Kolling Institute of Medical Research, B6, Royal North Shore Hospital, St. Leonards, New South Wales 2065 Australia, J Melrosenonspecific antibody binding. Materials and Methods Rat monoclonal anti-perlecan domain-IV (A7L6) (ab2501) antibody was obtained from Abcam, Cambridge, UK. Rabbit polyclonal anti-type VI collagen antisera (VIb)

(9) The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)Fluids and barriers of the CNSSeptember 29, 2020Damodarasamy M, Vernon RB, Pathan JL, Keene CD, Day AJ, Banks WA, Reed MJ.AB2033, Millipore-Sigma), or TSG-6 (RAH-1; [37]). A rat monoclonal antibody recognizing human HSPG2 (perlecan) (Item ab2501, Abcam) was also used. Primary antibodies bound to the blots were visualized with the appropriate horseradish

(10) Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque RuptureCirculation ResearchSeptember 25, 2020Tomáš Vaisar et al.fragment of COL18A1; Santa Cruz Biotechnology sc-32720; 1:100), and rat monoclonal anti-HSPG2 (Abcam ab2501; 1:100). Negative control primary antibodies and dilutions were rabbit IgG (R&D Systems AB-105-C; 1:1000),

(11) A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infectionScientific ReportsDecember 1, 2018Harry Horsley, Dhanuson Dharmasena, James Malone-Lee, Jennifer L. Rohnor 1:100 dilution of rat anti-heparan sulphate proteoglycan (large) monoclonal antibody (clone A7L6, ab2501, Abcam). Post incubation with primary antibodies, the tissue was washed 5 times with PBS containing

(12) Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal ProgenitorsStem cell reviewsAugust 1, 2017Sambi M, Chow T, Whiteley J, Li M, Chua S, Raileanu V, Rogers IM.NB159248), Laminin (Abcam ab11575), Fibronectin (Abcam ab23750), Collagen IV (Abcam ab6586), HSPG (Abcam ab2501), Vimentin (Santa Cruz sc7558), Podocin (Sigma P0372), panCytokeratin (Sigma p2871). Cells were stained

(13) Early changes in extracellular matrix in Alzheimer's diseaseNeuropathology and Applied NeurobiologyFebruary 1, 2017F.-X. Lepelletier, D. M. A. Mann, A. C. Robinson, E. Pinteaux, H. BoutinIV rabbit 1:500 Abcam (ab6586) Alexa Fluor 488 (A-21202) heparan sulphate proteoglycan (perlecan) rat 1:500 Abcam (ab2501) Alexa Fluor 594 (A-21209) fibronectin mouse 1:200 Sigma Aldrich (F0916) Alexa Fluor 594 (A-21203) human

(14) Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineagesFuture science OADecember 1, 2016Shu C, Smith SM, Little CB, Melrose J.

(15) Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral discEuropean cells & materialsJuly 5, 2016Hayes AJ, Shu CC, Lord MS, Little CB, Whitelock JM, Melrose J.fibrillin-1 and thus it Materials and Methods Materials Rat monoclonal anti-perlecan domain-IV (A7L6) (ab2501) and rabbit anti-type VI collagen (ab6588) polyclonal antibodies were obtained from Abcam through Sapphire Bioscience

(16) Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysisThe Journal of cell biologyDecember 21, 2015Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ.124695 (rabbit; Abcam), or 73402 (mouse; Abcam). For TACE, we used the rabbit antibodies ab75609 or ab2501 (both from Abcam). Rabbit antibody X81 (Xia et al., 1997a), directed against the first 81 residues of

(17) CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycansCardiovascular researchJuly 15, 2014Amit Saxena, Marcin Bujak, Olga Frunza, Marcin Dobaczewski, Carlos Gonzalez-Quesada, Bao Lu, Craig Gerard, Nikolaos G Frangogiannis

(18) A Splice Mutation and mRNA Decay of EXT2 Provoke Hereditary Multiple ExostosesPLoS ONEApril 11, 2014Chen Tian, Rengna Yan, Shuzhen Wen, Xueling Li, Tianfeng Li, Zhenming Cai, Xinxiu Li, Hong Du, Huimei Chenrabbit polyclonal antibody ab102843 from Abcam; and HS, rat monoclonal [A7L6] to HS proteoglycan (large) ab2501, from Abcam. The primary antibody for EXT2 targeted amino acid sequences 188–218 of human EXT2, a region

(19) Distinct spatio-temporal extracellular matrix accumulation within demyelinated spinal cord lesions in Theiler's murine encephalomyelitisBrain pathology (Zurich, Switzerland)March 1, 2012Haist V, Ulrich R, Kalkuhl A, Deschl U, Baumgärtner W.

(20) Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathyExperimental Eye ResearchFebruary 1, 2010Katja Schenke-Layland, Jiansong Xie, Mattias Magnusson, Ekaterini Angelis, Xiaodong Li, Kaijin Wu, Dieter P. Reinhardt, W. Robb MacLellan, Sarah F. Hamm-AlvarezCarpinteria/CA, USA); as well as II) monoclonal antibodies against heparan sulphate glycosaminoglycans (ab2501, 1:100; Abcam Inc.); tenascin C (T3413, 1:200; SigmaAldrich, St. Louis/MO, USA); MMP2 (MAB3308, 1:1000;

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Anti-Heparan Sulfate Proteoglycan 2/Perlecan antibody [A7L6] from Abcam

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Anti-Heparan Sulfate Proteoglycan 2/Perlecan antibody [A7L6] from Abcam

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