Anti-ADAM10 antibody ab1997 from Abcam

Product Specs
ItemAnti-ADAM10 antibody
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab1997
Antibody TypePrimary
HostRabbit
IsotypeIgG
ClonalityPolyclonal
Quantity100 UG
ApplicationsImmunocytochemistry, Immunocytochemistry/ Immunofluorescence, Western blot
Conjugate/TagUnconjugated
Concentration1 mg/ml
Gene NameADAM10
ReactivityHuman
TargetADAM10

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Construction of a Set of Novel Transposon Vectors for Efficient Silencing of Protein and lncRNA Genes via CRISPR InterferenceMolecular BiotechnologyOctober 1, 2023Maria Czarnek, Jakub Kochan, Mateusz Wawro, Rafał Myrczek, Joanna Beretawere transferred onto 0.45 μm PVDF membrane (Immobilon FL, Merck) and probed with rabbit anti-ADAM10 (ab1997, Abcam) at 1:5000 and then with HRP-conjugated secondary antibody (anti-rabbit, Cell Signaling Technology,

(2) Proteolysis of CD44 at the cell surface controls a downstream protease networkFrontiers in Molecular BiosciencesFebruary 17, 2023Birte Wöhner, Wenjia Li, Sven Hey, Alice Drobny, Ludwig Werny, Christoph Becker-Pauly, Ralph Lucius, Friederike Zunke, Stefan Linder, Philipp ArnoldC-term,Rabbit,Abcam ab157107 CD44 primary conjungated,Mouse,Cell Signaling Technology #3516 ADAM10,Rabbit,Abcam ab1997 MMP14,Mouse,Millipore MAB3328-25UG FLAG,Mouse,Sigma-Aldrich F1804 β-actin,Rabbit,Sigma-Aldrich A2066 Rabbit,Mouse,"Santa Cruz Biotechnology, Inc

(3) Injury to the tunica media initiates atherogenesis in the presence of hyperlipidemiaFrontiers in cardiovascular medicineJanuary 1, 2023Belhoul-Fakir H, Wu J, Yeow YL, Musk GC, Kershaw H, Ingley E, Zhao BS, Reid CM, Lagat C, Evans B, et al.cat# GTX104577), anti-MMP9 (Polyclonal, Abcam, cat# ab124513), and ADAM10 (Polyclonal, Abcam, cat# ab1997). For secondary detection, fluorescence-labelled, 488-conjugated anti-rabbit IgG (Abcam), 546-conjugated

(4) ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signalingNeural regeneration researchNovember 1, 2022McMillan N, Kirschen GW, Desai S, Xia E, Tsirka SE, Aguirre A.anti-ADAM10, clone 139712","R&D Systems, MAB946",AB_2222927 Rabbit polyclonal anti-ADAM10,"Abcam, ab1997",AB_302747 Rabbit polyclonal anti-doublecortin,"Abcam, ab18723",AB_732011 Rabbit monoclonal [Y135]

(5) HIV-Associated Insults Modulate ADAM10 and Its Regulator Sirtuin1 in an NMDA Receptor-Dependent MannerCellsSeptember 22, 2022Claudia Lopez Lloreda, Sarah Chowdhury, Shivesh Ghura, Elena Alvarez-Periel, Kelly Jordan-Sciuttoprimary antibodies overnight at 4 °C. The primary antibodies used and their dilutions were: ADAM10 (ab1997, 1:1000; Abcam, Cambridge, United Kingdom), SIRT1 (ab110304, 1:500; Abcam, Cambridge, United Kingdom,),

(6) The effect of citalopram treatment on amyloid-β precursor protein processing and oxidative stress in human hNSC-derived neuronsTranslational psychiatryJuly 18, 2022Elsworthy RJ, Crowe JA, King MC, Dunleavy C, Fisher E, Ludlam A, Parri HR, Hill EJ, Aldred S.Serotonin reuptake transporters (SERT) (702076, Invitrogen), AβPP (Merck, Mab348) and ADAM10 (Abcam, AB1997) were diluted in blocking buffer and added for 1 h. Following primary antibody incubation, cells were

(7) Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathologySignal transduction and targeted therapyJune 13, 2022Huang S, Zhang Z, Cao J, Yu Y, Pei G.(rabbit, ABclonal 1:1000, A0002), NCT (rabbit, Sigma-Aldrich 1:1000, N1660), ADAM10 (rabbit, Abcam 1:1000, ab1997), BACE1 (rabbit, Abgent 1:1000, AP7774b), β-actin (rabbit, Sigma-Aldrich 1:1000, A2066). Secondary antibody

(8) The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10The Journal of biological chemistryJune 1, 2022Hitschler L, Lang T.polyclonal antibodies specific for ADAM10 (diluted 1:1000 in immunofluorescence [IF]; catalog no.: ab1997; Abcam) and ADAM17 (diluted 1:500 in IF; catalog no.: AB19027; Merck), a mouse monoclonal antibody raised

(9) Berberine Suppresses Leukocyte Adherence by Downregulating CX3CL1 Expression and Shedding and ADAM10 in Lipopolysaccharide-Stimulated Vascular Endothelial CellsInternational Journal of Molecular SciencesApril 27, 2022Yi-Hong Wu, Chen-Ying Wei, Wei-Chin Hong, Jong-Hwei Su Pangfrom Sigma-Aldrich (St. Louis, MO, USA). Anti-CX3CL1 (ab25088), anti-CX3CR1 (ab8021), and anti-ADAM10 (ab1997) antibodies were obtained from Abcam (Cambridge, UK). Anti-phospho-STAT3 (D3A7), anti-RELA (D14E12),

(10) shRNAs targeting mouse Adam10 diminish cell response to proinflammatory stimuli independently of Adam10 silencingBiology openMarch 15, 2022Czarnek M, Stalińska K, Sarad K, Bereta J.rabbit-anti ADAM17 at 1:2500 (PA5-17080, Thermo Fisher Scientific) or rabbit anti-ADAM10 at 1:5000 (ab1997, Abcam) and then with HRP-conjugated secondary antibody (goat anti-rabbit at 1:10,000, Sigma-Aldrich).

(11) ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPcCancer Cell InternationalDecember 1, 2021Yuanyuan Cheng, Lishuang Lin, Xiaoyan Li, Aiqi Lu, Chenjian Hou, Qian Wu, Xiaomu Hu, Zhongwen Zhou, Zhongqing Chen, Feng Tangmembranes, blocked in 5% non-fat milk for 2 h, and incubated overnight with antibodies against ADAM10 (ab1997, Abcam, USA), PrPc (P0110, Sigma, USA), CD44 (3570, Cell Signaling Technology, USA), Notch1(3608, Cell Signaling Technology

(12) Sulfuretin exerts diversified functions in the processing of amyloid precursor proteinGenes & diseasesNovember 1, 2021Chen J, Luo B, Zhong BR, Li KY, Wen QX, Song L, Xiang XJ, Zhou GF, Hu LT, Deng XJ, et al.The final concentration of DMSO was no more than 1:1000. Antibody information was as follows: ADAM10 (ab1997, Abcam, 1:1000); BACE1 (ab2077, Abcam, 1:1000); APP-full length (A8717, Sigma, 1:3000); α-CTF and/or

(13) Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of ADBiologySeptember 19, 2021Lee HJ, Jeong HR, Park JH, Hoe HS.,Cell Signaling,9664 NEP,Rabbit,1:200,Millipore,AB5458 IDE,Rabbit,1:200,Abcam,AB32216 ADAM17,Rabbit,1:100,Abcam,AB2051 ADAM10,Rabbit,1:100,Abcam,AB1997 AT180,Mouse,1:100,Invitrogen,MN1040 Tau5,Mouse,1:100,Invitrogen,AHB0042 p-GSK-3βY216,Rabbit,1:200,Abcam,AB75745 p-CDK-5,Rabbit,1:200,LSBio,LS-C354604 DYRK1A,Rabbit,1:200,Abcam,AB69811 Primary

(14) NK Cells Lose Their Cytotoxicity Function against Cancer Stem Cell-Rich Radiotherapy-Resistant Breast Cancer Cell PopulationsInternational journal of molecular sciencesSeptember 6, 2021Jin H, Kim HJ.Abcam), anti-MICA/B (#ab203679, 1:1000, Abcam), anti-HLA-E (#ab2216, 1:1000, Abcam), anti-ADAM-10 (#ab1997, 1:1000, Abcam), and anti-β-actin (#MA5-15739, Thermo Fisher Scientific) antibodies for 1–2 days at

(15) TGF-β1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cellsBiochemistry and Biophysics ReportsSeptember 1, 2021Hirari Yamahana, Minoru Terashima, Risa Takatsuka, Chikako Asada, Takeshi Suzuki, Yoshihiro Uto, Takahisa Takino(Cell Signaling Technology, Danvers, MA, USA); anti-α-tubulin antibody (T9026, Sigma-Aldrich); anti-ADAM10 antibody (Abcam, ab1997, Cambridge, UK); Hoechst 33,342 and Alexa Fluor-labeled secondary antibodies (Invitrogen, Carlsbad,

(16) Therapeutic Effects of Aripiprazole in the 5xFAD Alzheimer’s Disease Mouse ModelInternational Journal of Molecular SciencesAugust 29, 2021Ye Ji Jeong, Yeonghoon Son, Hye-Jin Park, Se Jong Oh, Jae Yong Choi, Young-Gyu Ko, Hae-June LeeMembranes were incubated at 4 °C with anti-6E10 (1:1000, Sig-39320, Covance), anti-ADAM10 (1:1000, ab1997, Abcam, Cambridge, UK), anti-BACE (1:1000, sc-33711, Santa Cruz Biotechnology, Dallas, TX, USA), anti-GFAP

(17) Role of Adiponectin-Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exerciseAging cellJune 1, 2021You J, Sun L, Wang J, Sun F, Wang W, Wang D, Fan X, Liu D, Xu Z, Qiu C, et al.used. 4.2 Drugs and antibody The following primary antibodies were used: Rabbit anti ADAM10 (1:1000, ab1997, Abcam); Goat anti ADAM17 (1:1000, ab13535, Abcam); Rabbit anti Notch1 (1:1000, ab27526, Abcam); Rabbit

(18) TREM2 expression in the brain and biological fluids in prion diseasesActa NeuropathologicaJune 1, 2021Daniela Diaz-Lucena et al.diluted 1:100 was used for immunohistochemistry for comparative purposes. Human ADAM10 antibody (Abcam, ab1997) was used at a dilution of 1:75 for immunohistochemistry and 1:500 for western blotting. Monoclonal

(19) Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathwayAging (Albany NY)February 28, 2021Xian-Qiang Ni et al.(ab214185), caspase-1 (ab1872), CD68 (ab955), CD16 (ab203883), Arg1 (ab91279), CD206 (ab64693, ADAM10 (ab1997), ADAM17 (ab2051), IL-1β (ab2105), IL-10 (ab9969) and IL-18 (ab191860) were from Abcam (Cambridge, UK).

(20) Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure: A Pilot StudyJournal of Clinical MedicineFebruary 14, 2021Renate Pichler, Andrea Katharina Lindner, Georg Schäfer, Gennadi Tulchiner, Nina Staudacher, Martin Mayr, Eva Comperat, Jacob J. Orme, Gert Schachtner, Martin ThurnherAdam17, dilution 1:100, Abcam ab2051), ADAM10 (Polyclonal Rabbit AntiHuman Adam10, dilution 1:500, Abcam ab1997), IL-10 (Polyclonal Rabbit Anti-Human IL-10, dilution 1:100, Abcam ab84843), and IL-10R (Polyclonal

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2/9/2022Very Good ADAM10 Antibody for WBDr. Christian OstaleckiThe aim of this research was to study the expression and activation levels of metallo proteases in DCs (immature and mature).

Anti-ADAM10 antibody from Abcam

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Anti-ADAM10 antibody from Abcam

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