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Antibodies
Anti-BACE1 antibody
Anti-BACE1 antibody from Abcam
Be the first to write a review!
Citations:
(76)
Supplier Page
Supplier Page from
Abcam for
Anti-BACE1 antibody
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-BACE1 antibody
Company
Abcam
Price
Supplier Page
View Company Product Page
Catalog Number
ab2077
Antibody Type
Primary
Applications
Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
Host
Rabbit
Quantity
100 UG
Clonality
Polyclonal
Isotype
IgG
Conjugate/Tag
Unconjugated
Concentration
1 mg/ml
Gene Name
Bace1
Reactivity
Human, Mouse
Target
BACE1
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (76)
(1)
Oleracone F Alleviates Cognitive Impairment and Neuropathology in APPswe/PSEN1dE9 Mice by Reducing the Expression of Vascular Cell Adhesion Molecule and Leukocyte Adhesion to Brain Vascular Endothelial Cells
International Journal of Molecular Sciences
January 20, 2023
Young-Sun Kwon, Jin-Sung Ko, Se-Young Oh, Young Taek Han, Sangmee Ahn Jo
monoclonal,Biolegend,SIG-39320 Anti-β-amyloid(4G8),
Mouse
monoclonal,Biolegend,SIG-39200 Anti-BACE1,Rabbit polyclonal,
Abcam
,
Ab2077
Anti-β-actin,Mouse monoclonal,
Abcam
,
Ab6276
List of antibodies
for Western blot
analysis and
immunofluorescence
(2)
AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice
Traffic (Copenhagen, Denmark)
January 1, 2023
Wen QX, Luo B, Xie XY, Zhou GF, Chen J, Song L, Liu Y, Xie SQ, Chen L, Li KY,
et al
.
as follow:
AP2S1
(
ab128950
,
Abcam
,
1:1000
),
APP
‐full length and CTFs (
A8717
,
Sigma
,
1:1000
), BACE1 (
ab2077
,
Abcam
,
1:1000
), sAPP‐β (SIG‐39138, Biolegend,
1:500
),
VPS41
(
ab181078
,
Abcam
,
1:1000
),
VPS16
(
17776‐1‐AP
,
(3)
The interrelationships between neuronal viability, synaptic integrity, microglial responses, and amyloid-beta formation in an in vitro neurotrauma model
Scientific reports
December 20, 2022
Wang LW, Lin HJ, Chao CM, Lin MT, Wang LY, Chein LH, Chang CP, Chio CC.
against amyloid precursor protein (APP;
1:30,000
, #
ab32136
,
Abcam
), beta-secretase 1 (BACE1;
1: 4000
, #
ab2077
,
Abcam
), Aβ (
1:8000
, #
ab62658
,
Abcam
), and β-actin (
1:5000
, #Sc-4778, Santa Cruz). On the next day,
(4)
Interleukin 17A deficiency alleviates neuroinflammation and cognitive impairment in an experimental model of diabetic encephalopathy
Neural Regeneration Research
June 6, 2022
Xiao-Xia Fang, Yu-Ping Peng, Xiao-Xia Fang, Fen-Fen Cao, Yi-Hua Liu, Bei-Bei Peng
Cat#
ab167161
, RRID: AB_2756463), rabbit anti-β-amyloid cleavage enzyme 1 (BACE1;
1:1000
;
Abcam
Cat#
ab2077
, RRID: AB_302817), rabbit
anti-tau (phospho S396
) (
1:1000
;
Abcam
Cat#
ab109390
, RRID:AB_10860822), rabbit
(5)
Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease
Frontiers in Nutrition
May 18, 2022
Liang Gu et al.
(
ab92676
), pT231-
Tau
(
ab151559
), MAP2 (
ab5392
), PP2Aα (
ab137825
), PP2Aα+β (
ab32104
), APP (
ab32136
), BACE1 (
ab2077
) and horseradish peroxidase (HRP)-conjugated secondary antibodies were bought from
Abcam
(Cambridge,
(6)
Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription
Aging Cell
May 1, 2022
De‐Juan Yuan et al.
Laboratories), rabbit polyclonal
anti‐Nav1.2
(
1:200
) (
ASC‐002
,
Alomone
Laboratories), BACE1 (
1:1000
) (
ab2077
,
Abcam
), Phospho‐
NFAT1
(
1:500
) (
AF8011
,
Affinity Biosciences
),
NFAT1
(
1:500
) (
DF7189
,
Affinity Biosciences
),
(7)
Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation
Scientific Reports
December 1, 2021
Luz Camacho-Castillo, Bryan V. Phillips-Farfán, Gabriela Rosas-Mendoza, Aidee Baires-López, Danira Toral-Ríos, Victoria Campos-Peña, Karla Carvajal
9018
,
Cell Signaling
Inc.), PKB/AKT (610860, BD Transduction Laboratories), APP, BACE-1 (
ab126873
,
ab2077
,
Abcam
), umtCK (
sc-15166
,
Santa Cruz Biotechnology Inc
.) and
NRF2
(
ADI-KAP-TF125-D
,
Enzo
).
Membranes
(8)
Sulfuretin exerts diversified functions in the processing of amyloid precursor protein
Genes & diseases
November 1, 2021
Chen J, Luo B, Zhong BR, Li KY, Wen QX, Song L, Xiang XJ, Zhou GF, Hu LT, Deng XJ,
et al
.
was no more than
1:1000
. Antibody information was as follows: ADAM10 (
ab1997
,
Abcam
,
1:1000
); BACE1 (
ab2077
,
Abcam
,
1:1000
);
APP
-full length (
A8717
,
Sigma
,
1:3000
); α-CTF and/or β-CTF:
A8717
(Sigma;
1:3000
),
(9)
Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury
Cell death discovery
October 23, 2021
Liao S, Apaijai N, Luo Y, Wu J, Chunchai T, Singhanat K, Arunsak B, Benjanuwattra J, Chattipakorn N, Chattipakorn SC.
(Cat.#
ab125066
,
1:1000
dilution,
Abcam
), ACSL4 (Cat.# sc-365230,
1:1000
dilution, SCBT), BACE1 (Cat.#
ab2077
,
1:1000
dilution,
Abcam
),
SOD2
(Cat.#
13194
,
1:1000
dilution,
CST
), and β-Actin (Cat.# sc-47778,
1:1000
(10)
Cornel Iridoid Glycoside Ameliorated Alzheimer’s Disease-Like Pathologies and Necroptosis through RIPK1/MLKL Pathway in Young and Aged SAMP8 Mice
Evidence-Based Complementary and Alternative Medicine
August 23, 2021
Denglei Ma, Yanzheng Li, Yanqiu Zhu, Weipeng Wei, Li Zhang, Yali Li, Lin Li, Lan Zhang
,
1 : 1000
,Covance,SIG-39139,WB
ADAM10
,Poly-,R,
1 : 1000
,
Sigma
,
A2726
,WB BACE-1,Poly-,R,
1 : 1000
,
Abcam
,
ab2077
,WB
RIPK1
,Mono-,R,
1 : 1000
,
CST
,
3493
,WB p-MLKL (Ser345),Mono -,R,
1 : 1000
,
CST
,
37333
,WB
MLKL
,Mono -,R,
1 : 1000
(11)
Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease
Neural Regeneration Research
March 1, 2021
Yan-Zhen Zhou, Gui-Qiong Liu, Yan-Zhen Zhang, Yuan-Jie Liu, Wei Zhang, Gui-Qiong Luo
ab241592
;
1:1000
;
Abcam
, Cambridge, MA, USA), β-amyloid precursor protein cleavage enzyme-1 (BACE1; Cat#
ab2077
;
1:1000
;
Abcam
), presenilin-1 (PS1; Cat#
ab76083
;
1:1000
;
Abcam
), insulin-degrading enzyme (IDE; Cat#
(12)
The Molecular Mechanism of Chronic High-Dose Corticosterone-Induced Aggravation of Cognitive Impairment in APP/PS1 Transgenic Mice
Frontiers in Molecular Neuroscience
January 15, 2021
Shen-Qing Zhang, Long-Long Cao, Yun-Yue Liang, Pu Wang
Louis, MO, USA). Antibodies against
APP
(ab241592, rabbit,
1:2,000
for Western blot
analysis), BACE1 (
ab2077
, rabbit,
1:2,000
for Western blot
analysis;
1:100
for IHC
and
immunofluorescence, IF
) and
NeuN
(
ab104224
,
(13)
Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice
Alzheimer's research & therapy
January 4, 2021
Su Q, Li T, He PF, Lu XC, Yu Q, Gao QC, Wang ZJ, Wu MN, Yang D, Qi JS.
anti-p62 (
ab109012
,
Abcam
), anti-NEP (
ab81688
,
Abcam
), anti-ubiquitin (
ab134953
,
Abcam
), anti-BACE1 (
ab2077
,
Abcam
), anti-LRP1 (
ab92544
,
Abcam
), anti-Beclin 1 (
ab207612
,
Abcam
), anti-albumin (
ab207327
,
Abcam
),
(14)
Chronic Periodontitis and Alzheimer Disease: A Putative Link of Serum Proteins Identification by 2D-DIGE Proteomics
Frontiers in Aging Neuroscience
August 21, 2020
Xianfang Rong, Liping Xiang, Yanfen Li, Hongfa Yang, Weijian Chen, Lei Li, Defeng Liang, Xincai Zhou
(Cell Signal Technology, 29765), AntisAPPα (
IBL
,
11088
), Anti-sAPPβ (
IBL
,
18957
) Anti-BACE1 (
Abcam
,
ab2077
), anti-ADAM10 (Cell Signal Technology, 14194) and anti-β-actin (Cell Signal Technology, 3700) overnight at
(15)
Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1
Cell death & disease
June 18, 2020
Kim SY, Chae CW, Lee HJ, Jung YH, Choi GE, Kim JS, Lim JR, Lee JE, Cho JH, Park H,
et al
.
purchased from
Santa Cruz Biotechnology
(Santa Cruz, CA, USA). The antibodies of APP (
ab32136
),
BACE1
(
ab2077
),
Sp1
(
ab227383
), NRF2 (
ab89443
), and Aβ (
ab2530
) were purchased from
Abcam
(Cambridge, England). The
(16)
SRC-1 Knockout Exerts No Effect on Amyloid β Deposition in APP/PS1 Mice
Frontiers in Aging Neuroscience
June 17, 2020
Qiong Wu et al.
APP
(87 KD,
1:1,000
,
Abcam
,
ab15272
); beta-site APP-cleaving enzyme 1 (BACE-1; 70 KD,
1:1,000
,
Abcam
,
ab2077
); β-actin (
1:2,000
,
Abcam
,
ab6276
). The following day, the
membranes
were washed in TBST three times,
(17)
Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer's disease patients, animal models and cell models
Aging
June 13, 2020
Long Z, Chen J, Zhao Y, Zhou W, Yao Q, Wang Y, He G.
Cell Signaling Technology
, USA), rabbit anti-APP (
ab32136
), rabbit anti-BECN-1 (
ab62557
), rabbit anti-BACE1 (
ab2077
), rabbit anti-PS1 (
ab71181
), rabbit anti-Lamp1 (
ab24170
),
mouse
anti-amyloid precursor protein (
ab32137
),
(18)
EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired
International Journal of Molecular Sciences
May 14, 2020
Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu
(
sc-166490
),
GAPDH
(
sc-81545
) were from
Santa Cruz Biotechnology
(Dallas, TX, USA); rabbit α-BACE1 (
ab2077
), rabbit α-calnexin (
ab22595
), rabbit α-
OS-9
(
ab19853
), rabbit α-
XTP3-B
(
ab181166
), rabbit α-tubulin
(19)
A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer’s Enzyme Biomarkers-BACE1 and Cathepsin D
Molecules
January 9, 2020
Jenny M. Tam, Lee Josephson, Alexander R. Pilozzi, Xudong Huang
stripping buffer (
Restore Western Blot Stripping Buffer
,
ThermoScientific
), re-probed with BACE1 antibody (
ab2077
) (
Abcam
, Cambridge, MA), and incubated with HRP (
horseradish
peroxidase)-conjugated
goat
anti-rabbit
(20)
β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice
The Korean Journal of Physiology & Pharmacology
January 1, 2020
Jian-Ya Ye, Li Li, Qing-Mao Hao, Yong Qin, Chang-Sheng Ma
primary antibodies were used: anti-Aβ (6E10,
1:1000
; Covance, Emeryville, CA, USA), anti-BACE1 (
1:500
,
ab2077
;
Abcam
, Cambridge, MA, USA), and anti-β-Actin (
1:500
,
ab2077
; Abcam). Band intensities were semi-quantified
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Anti-BACE1 antibody from Abcam
Supplier Page
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