Fig 1: The disparity of apoptotic, anti-apoptotic, autophagy markers. Bar diagrams showing apoptotic markers as caspase-3, caspase-8, P53 (A), Bcl2, KI-67 as proliferation markers (B), ATG4B (C) and ATG5 (D) as autophagic markers of MCF-7 cells (I) and MCF-7 Xenograft mice (II) treated with single or combinatorial treatments. The data are presented as mean ± SE of at least three independent experiments. # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001 compared with control (untreated group). + p < 0.05, ++ p < 0.01, +++ p < 0.001, ++++ p < 0.0001 compared with the DOX treated group.