Fig 1: Effect of Dun on IMQ-induced inflammatory cytokines in NQO1-/- mice. (A) mRNA expression levels of IL-17A, IL-17F, IL-22, and IL-23 determined by quantitative RT-PCR in dorsal skin of NQO1-/- mice after 6 days of IMQ treatment. (B) Levels of IL-17, IL-22 and IL-23 in homogenized skin tissue measured using ELISA. Bars represent mean ± S.D. (n = 5). #p < 0.05 compared with the control group.
Fig 2: Dun inhibits IMQ-induced inflammatory cytokines in skin lesions of C57BL/6 mice. mRNA expression levels of IL-17A, IL-17F, IL-22, and IL-23 determined by quantitative RT-PCR in dorsal (A) and ear (B) skin after 6 days of IMQ treatment. (C) Levels of IL-17, IL-22 and IL-23 in homogenized skin tissue measured using ELISA. Bars represent mean ± S.D. (n = 5). #, *Indicate p < 0.05 compared with the control (#) and IMQ (*) groups.
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