Fig 1: Methodological verification of HSPE1 in individual urine specimens from BC and hernia patients by antibody-based analysis(A) Expression of HSPE1 in individual clinical urine specimens from BC and hernia patients, detected by Western blot analysis using an anti-HSPE1 antibody. A pooled urine sample prepared from BC and hernia patients was used as control for comparison of multiple gels. Data were quantified using Image J software. (B–D) Results of statistical analyses of HSPE1 expression in urine from hernia and BC patients by ELISA. (B) Differences in HSPE1 concentrations in urine specimens from hernia (n = 142), BC (n = 59), hematuria (n = 67) and UTI (n = 59) patients. (C) Difference in HSPE1 concentration in urine specimens from hernia (n = 142), low-grade BC (n = 42) and high-grade BC (n = 84) patients. (D) Difference in HSPE1 concentration in urine specimens from hernia (n = 142), early-stage BC (n = 98), and advanced-stage BC (n = 28) patients. Differences between groups were determined using the Mann-Whitney test.
Fig 2: Up-regulation of HSPE1 in individual bladder tumor tissue specimens, determined by IHC(A) IHC scores for normal tissue (n = 19) and tumor tissue (n = 92) in bladder tumor slides. (B) IHC score for adjacent normal tissue (n = 19) and paired tumor tissue (n = 19) in paired bladder tumor slides. HSPE1 expression data for normal and tumor tissue cells from a given individual are linked with dashed lines. Differences between groups were determined using the Mann-Whitney test for (A) and paired Student's t-test for (B).
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