Fig 1: CXCR2 drives the chemotaxis of peripheral monocytes toward TBI CSF. A Typical Transwell images of chemotaxis of peripheral monocytes, isolated from patients with TBI/non-TBI, toward TBI/non-TBI CSF, or SH-SY5Y cell line conditioned medium (CM). B The chemotaxis number of peripheral monocytes, isolated from patients with TBI/non-TBI, toward TBI/non-TBI CSF, or SH-SY5Y cell line CM after 16 h. **P < 0.01, determined by paired t tests. C Levels of CXCL1, CXCL2, and CXCL8 in CSF of TBI or non-TBI patients. The dashed line represents average value of each chemokine in non-TBI CSF. *P < 0.05, **P < 0.01, TBI vs. non-TBI, determined by unpaired t tests or Mann–Whitney tests. D Typical Transwell images of chemotaxis of peripheral monocytes, isolated from patients with TBI/non-TBI and pretreated by DMSO (vehicle control) or SB225002, toward TBI CSF. E The chemotaxis number of peripheral monocytes, isolated from patients with TBI/non-TBI and pretreated by DMSO (vehicle control) or SB225002, toward TBI CSF after 16 h. **P < 0.01, determined by paired t tests. Data are presented as mean with SEM