Fig 1: Time course effect of 2-ME on liver p53 (5A), Bax (5B), Bcl-2 (5C) and caspase-3 (5D) levels. Values are expressed as mean ± standard error of the mean. Bars labeled with different letters are statistically significant (p < 0.05).
Fig 2: Levels of KIM-1 (A), HMGB-1 (B), caspase 3 (C), GPX (D), SOD (E), NF-?B (F) and p53 (G). Bars represent mean ± SD. Followed by post hoc Dunnett test, significant difference was analyzed by one-way ANOVA test, where * p < 0.001, compared to the sham group, and # p < 0.001, compared to the IR group. KIM-1; kidney injury molecule-1, GPX; glutathione peroxidase, SOD; superoxide dismutase, NF-?B; nuclear factor-?B, SD; standard deviation, IR; ischemia reperfusion.
Fig 3: The renal expression of IL-1ß, IL6, IL10, TNF-a, NF-?B, p53, and bax genes. Quantitative RT-PCR was used to investigate the gene expression of different groups. Expression was represented relative to the untreated sham group and normalized to the corresponding GAPDH gene expression. Bars represent mean ± SD. Followed by post hoc Dunnett test, significant difference was analyzed by two-way ANOVA test, where **; p < 0.01, ***; p < 0.001, compared to the sham group, and #, p < 0.05; ###, p < 0.001, compared to the IR group. IL; interleukin, TNF-a; tumor necrosis factor-a, NF-?B; nuclear factor-?B, SD; standard deviation, IR; ischemia reperfusion.
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