Fig 1: Time course effect of 2-ME on liver p53 (5A), Bax (5B), Bcl-2 (5C) and caspase-3 (5D) levels. Values are expressed as mean ± standard error of the mean. Bars labeled with different letters are statistically significant (p < 0.05).
Fig 2: Levels of KIM-1 (A), HMGB-1 (B), caspase 3 (C), GPX (D), SOD (E), NF-κB (F) and p53 (G). Bars represent mean ± SD. Followed by post hoc Dunnett test, significant difference was analyzed by one-way ANOVA test, where * p < 0.001, compared to the sham group, and # p < 0.001, compared to the IR group. KIM-1; kidney injury molecule-1, GPX; glutathione peroxidase, SOD; superoxide dismutase, NF-κB; nuclear factor-κB, SD; standard deviation, IR; ischemia reperfusion.
Fig 3: Effect of PAs and CCl4 on (A) pro-apoptotic proteins Bax and (B) anti-apoptotic protein Bcl-2, (C) caspase-9, and (D) caspase-3 levels in the liver of control and experimental groups. These parameters are expressed as the unit per gram wet tissue. Data are expressed as mean ± SEM (n = 6 for each group). a, b, c Significant change at P < 0.05. a: Significance as compared with control, b: significance as compared with CCl4 group in 5 weeks, c: significance as compared with CCl4 group in 9 weeks. Cont, control; O oil, olive oil; proanthocyanidins, PAs; CCl4, carbon tetrachloride
Fig 4: CuNPs and low-dose gamma irradiation exposure effect on mice bearing Ehrlich tumor. Parameters detected in the tumor tissue homogenate were A concentration, B MDA level, C GSH content, D CAT activity, and E caspase-3. Where EC, Ehrlich carcinoma; CuNPs, copper nanoparticles, and R, low dose gamma radiation. Data were represented by mean ± SD (n = 6). Statistically significant differences were assessed by a one-way ANOVA followed by post hoc test. Data were considered significant at p ≤ 0.05. Where a, significance compared to control; b, significance compared to EC; c, significance compared to EC/CuNPs; d, significance compared to EC/R; e, significance compared to EC/CuNPs/R
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