Fig 1: LIGHT contributes to monocyte migration and macrophage M2 polarization. a Representative images of mouse cardiac tissues from the different groups with CD3, F4/80, MCP1, iNOS, CD163, and CD206 IHC staining (from above to below). b Quantification of CD3+, F4/80+, MCP1+, iNOS+, CD163+, and CD206+ areas in the different groups. c mRNA levels of MCP1, TNF-a, IL-1ß, IL-10, TGF-ß1, ARG1, and CD163 in the different groups [relative to the LIGHT( -) group]. d Elevation in the serum levels of TNF-a, IL-1ß, TGF-ß1, IL-10, and IL4 from different groups. e Western blot analysis of MCP1, iNOS, TGF-ß1, ARG1, CD163, and CD206, and f relative expression in the cardiac tissue normalized to the control. *p < 0.05, **p < 0.01. MCP1: monocyte chemoattractant protein-1; TNF-a: tumour Necrosis Factor a; IL-1ß: interleukin 1ß; IL-10: interleukin 10; TGF-ß1: transforming growth factor ß; ARG1: arginase1
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