Fig 1: Aberrant cytokine identification in lesions of AD patients with atopic march. (A) Vann diagram showing the number of AM-associated genes in the red circle. (B) Top 10 enriched KEGG pathways, P < 0.05. (C) Sample cluster analyses based on the expression pattern of DEGs involved in cytokine-cytokine receptor interactions [LNR group (n = 3), LR group (n = 6)]. (D) The expression levels of DEGs enriched in cytokine-cytokine receptor interactions in the microarray of AM [HS group (n = 3), AD group (n = 4), AM group (n = 3)]. (E) The mRNA expression levels of IL17A and IL4R in the skin. (F) The protein expression levels of IL17A and IL4R in the skin and (G) serum [HNR group (n = 5), LNR group (n = 11), LR group (n = 15)]. (H) The correlation of skin IL17A and IL4R with TNSS (n = 11). *P < 0.05, **P < 0.01, ***P < 0.001 according to one-way ANOVA followed by Tukey’s or Dunnett’s multiple comparisons.